| Cat. No. |
Product Name |
Information |
| PC-21258 |
M109S
Bax inhibitor
|
M109S is a small molecule protecting cells from mitochondria-dependent apoptosis wtih EC50 of 23.4 nM in iBax cells, directly interacts with Bax (Kd=153 nM, MST assay) and inhibits Bax activation. |
| PC-21117 |
PDCD2 ligand 7e
PDCD2 modulator
|
PDCD2 ligand 7e is a small molecule that may directly bind to PDCD2, rescues PDCD2 degradation induced by PDCD2 degrader 10e. |
| PC-21059 |
WK499
BCL-6 inhibitor
|
WK499 (WK-499) is a small molecule inhibitor of BCL6 with IC50 of 11.7 nM in HTRF assay, directly binds to BCL6 BTB (SPR KD=148 nM), inhibits the BCL6-mediated transcriptional repression activity. |
| PC-20689 |
BAU-243
Bcl-2 inhibitor
|
BAU-243 (BAU243) is a novel BH3 mimetic Bcl-2 inhibitor with a high affinity, effectively reduces overall GBM cell proliferation including a subpopulation of cancer-initiating cells. |
| PC-20626 |
CCT373567
BCL6 inhibitor
|
CCT373567 is a potent, selective and cell-active BCL6 inhibitor with IC50 of 2.9 nM in TR-FRET assays, and 25.9 nM in NanoBRET cellular inhibition assays. |
| PC-20511 |
ABBV-167
BCL-2 inhibitor
|
ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax. |
| PC-20503 |
CCT374705
BCL6 inhibitor
|
CCT374705 is a potent, selective, in-vivo active BCL6 inhibitor with TR-FRET IC50 of 6 nM. |
| PC-20245 |
CGDF-190-20
BFL-1 inhibitor
|
CGDF-190-20 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 365 nM in FP assays. |
| PC-20244 |
CGDF-183-20
BFL-1 inhibitor
|
CGDF-183-20 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 264 nM in FP assays. |
| PC-20243 |
BDM53787
BFL-1 inhibitor
|
BDM53787 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 0.8 uM (inhibition FITC–Bim BH3 binding to Bfl-1). |
| PC-20242 |
BDM49234
BFL-1 inhibitor
|
BDM49234 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 6.3 uM (inhibition FITC–Bim BH3 binding to Bfl-1). |
| PC-20241 |
BDM44898
BFL-1 inhibitor
|
BDM44898 is a small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 1.6 uM. |
