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Cat. No. Product Name Information
PC-20242

BDM49234

BFL-1 inhibitor

BDM49234 is a selective small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 6.3 uM (inhibition FITC–Bim BH3 binding to Bfl-1).
PC-20241

BDM44898

BFL-1 inhibitor

BDM44898 is a small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 1.6 uM.
PC-20240

BDM44931

BFL-1 inhibitor

BDM44931 is a small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 1.3 uM.
PC-49852

MI-238

Mcl-1 inhibitor

MI-238 (MI 238) is a potent and specific Mcl-1 inhibitor with Ki of 0.45 uM to human Mcl-1 protein in FP assays, disrupts the association of Mcl-1 with BH3-only proteins.
PC-49799

BM-1197

Bcl-2/Bcl-xL inhibitor

BM-1197 (BM1197) is a potent and efficacious dual inhibitor of Bcl-2 and Bcl-xL with Ki of < 1 nM, >1,000-fold selectivity over Mcl-1.
PC-49798

Pelcitoclax

Bcl-2/Bcl-xL inhibitor

Pelcitoclax (APG-1252, BM-1252) is a potent dual specific Bcl-2/Bcl-xL inhibitor with Ki of < 1 nM, shows potent antitumor effects with minimal platelet toxicity.
PC-49791

OICR12694

Bcl-6 BTB inhibitor

OICR12694 (OICR 12694, JNJ-65234637) is a potent, selective, and orally bioavailable BCL6-BTB inhibitor with SPR KD value of 5 nM.
PC-49764

Venetoclax

Bcl-2 inhibitor

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with Ki value of <0.01 nM.
PC-49189

DC-B01

BCL2 BH4 inhibitor

DC-B01 is a novel small molecule BCL-2 inhibitor that binds to the BH4 domain with KD of 2.16 uM, disrupts the BCL-2/c-Myc interaction and consequently suppresses the transcriptional activity of c-Myc.
PC-38807

CCT373566

BCL6 degarder

CCT373566 is a highly potent, in vivo active BCL6 degarder with IC50 of 2.2 nM and DC50 of 0.7 nM in TR-FRET and cellular BCL6 degradation assays, respectively.
PC-38806

CCT372064

BCL6 inhibitor

CCT372064 is a potent, ligand-efficient inhibitor of BCL6 with IC50 of 3.9 nM and 12 nM in TR-FRET and cellular NanoBRET assays, respectively.
PC-38660

GSK137

BCL6 inhibitor

GSK137 is a potent, small-molecule BCL6 inhibitor binding to BCL6 BTB-POZ domain, displaces peptides derived from the human SMRT co-repressor from the BCL6 BTB-POZ domain in a TR-FRET assay with a pIC50 of 8.0.

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