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Cat. No. Product Name Information
PC-35590

BXI-72

BCL-XL inhibitor

BXI-72 (NSC334072, Hoechst 33342) is a potent, selective small molecule Bcl-XL inhibitor that targets the BH3 domain of Bcl-XL (Kd=0.9 nM).
PC-35318

BRD1991

Beclin 1/Bcl-2 inhibitor

BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity..
PC-35317

SW076956

Beclin 1/Bcl-2 inhibitor

SW076956 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity..
PC-35316

SW063058

Beclin 1/Bcl-2 inhibitor

SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity..
PC-43514

Apogossypol

BCL-2 inhibitor

Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.
PC-63502

S55746

BCL-2 inhibitor

S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1.
PC-63501

S55746 hydrochloride

BCL-2 inhibitor

S55746 (BCL201, Servier-1) hydrochloride is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1.
PC-43235

Mcl1-IN-2

Mcl-1 inhibitor

Mcl1-IN-2 (IMB-XH1) is an Mcl-1 inhibitor without a reported IC50 value, also is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor with IC50 of 0.46 uM.
PC-63211

Sabutoclax

BCL-2 inhibitor

Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM.
PC-43096

Pyridoclax

Mcl-1 inhibitor

Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
PC-43048

A-1210477

Mcl-1 inhibitor

A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes, shows much weaker against Bcl-2 (Ki=132 nM) and Bcl-XL (Ki>660 nM).
PC-62553

Disarib

BCL2-BAK inhibitor

Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.).

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