| Cat. No. |
Product Name |
Information |
| PC-25072 |
Mesutoclax
BCL-2 inhibitor
|
Mesutoclax (ICP-248) is a highly selective and potent, orally active BCL-2 inhibitor with IC50 of 1.54 nM, shows no activity against BCL-xL(IC50>1 uM). |
| PC-25038 |
Dalvotoclax
BCL-2 inhibitor
|
Dalvotoclax is a potent, selective inhibitor of anti-apoptotic protein Bcl-2. |
| PC-24935 |
Asaretoclax
BCL-2 inhibitor
|
Asaretoclax (ZN-d5) is a potent, selective and orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. |
| PC-24442 |
Foselutoclax
BCL-xL inhibitor
|
Foselutoclax (UBX1325, UBX0601 prodrug) is a senolytic small-molecule inhibitor of BCL-xL. |
| PC-24290 |
WEHI-3773
VDAC2-BAX inhibitor
|
WEHI-3773 is a small molecule inhibitor of interaction between VDAC2 and BAX, inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria. |
| PC-24151 |
Lonitoclax
BCL-2 inhibitor
|
Lonitoclax (ZE50-0134) is a potent, selective next generation BCL-2 inhibitor, a key pro-survival protein that is overexpressed in many cancers, for the treatment of AML and CLL. |
| PC-23978 |
Bcl-3 inhibitor A27
Bcl-3 inhibitor
|
Bcl-3 inhibitor A27 is a specific small molecule inhibitor of proto-oncogene Bcl-3, inhibits Bcl-3-mediated cyclin D1 expression and promoter activity, affects the binding between Bcl-3 and the NF-κB transcription factor p50, without affecting the classical NF-κB activation. |
| PC-23835 |
AMG-397
Mcl-1 inhibitor
|
Murizatoclax (AMG-397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor with Ki of 15 pM. |
| PC-23834 |
ABBV-467
Mcl-1 inhibitor
|
ABBV-467 is a highly potent and selective MCL-1 inhibitor with TR-FRET Ki of <0.01 nM, >25,000-fold seletive over other BCL-2 family proteins BCL-XL, BCL-2, BCL-W, and BCL2-A1. |
| PC-23607 |
BFL-1 inhibitor 20 hydrochloride
BFL-1 inhibitor
|
BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL-1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1. |
| PC-23130 |
WK692
BCL6 inhibitor
|
WK692 is a specific small molecule BCL6 inhibitor, directly binds to BCL6 BTB domain (SPR, KD=324 nM), disrupts BCL6BTB/SMRT interaction (IC50=16 nM) and activates the expression of BCL6 downstream genes in cancer cells. |
| PC-23094 |
Lacutoclax
Bcl-2 inhibitor
|
Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax. |
