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Cat. No. Product Name Information
PC-42756

Obatoclax

Bcl-2 inhibitor

Obatoclax (GX15-070) mesylate is a potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
PC-45490

UMI-77

Mcl-1 inhibitor

UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM.
PC-45314

Gossypol acetic acid

BCL-2 inhibitor

Gossypol acetic acid ((±)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
PC-44439

AT-101

BCL-2 inhibitor

AT-101 ((R)-(-)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
PC-43513

Gossypol

BCL-2 inhibitor

Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
PC-42244

S63845

Mcl-1 inhibitor

S63845 is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM).
PC-47486

Bax inhibitor peptide V5

Bax inhibitor

Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation.
PC-45901

ABT-737

BCL-2 inhibitor

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively.
PC-25072

Mesutoclax

BCL-2 inhibitor

Mesutoclax (ICP-248) is a highly selective and potent, orally active BCL2 inhibitor.
PC-25038

Dalvotoclax

BCL-2 inhibitor

Dalvotoclax is a potent, selective inhibitor of anti-apoptotic protein Bcl-2.
PC-24935

Asaretoclax

BCL-2 inhibitor

Asaretoclax (ZN-d5) is a potent, selective and orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities.
PC-24442

Foselutoclax

BCL-xL inhibitor

Foselutoclax (UBX1325) is a senolytic small-molecule inhibitor of BCL-xL.

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