| Cat. No. |
Product Name |
Information |
| PC-43513 |
Gossypol
BCL-2 inhibitor
|
Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
| PC-42244 |
S-63845
Mcl-1 inhibitor
|
S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM). |
| PC-47486 |
Bax inhibitor peptide V5
Bax inhibitor
|
Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation. |
| PC-45901 |
ABT-737
BCL-2 inhibitor
|
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively. |
| PC-23607 |
BFL1 inhibitor 20
BFL1 inhibitor
|
BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1. |
| PC-23094 |
Lacutoclax
Bcl-2 inhibitor
|
Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax. |
| PC-23065 |
Bfl-1 inhibitor (R,R,S)-26
Bfl-1 inhibitor
|
Bfl-1 inhibitor (R,R,S)-26 is a potent, selective, covalent, cell active Bfl-1 inhibitor with IC50 of 22 nM, shows no activity against Bcl-xl, Bcl-2 and Mcl-1 (IC50>30 uM). |
| PC-22977 |
BRD-810
Mcl-1 inhibitor
|
BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein. |
| PC-22111 |
TUDCA
Bax inhibitor
|
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis. |
| PC-22106 |
BAM7
Bax activator
|
BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX. |
| PC-22105 |
CBI1
Bax inhibitor
|
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis. |
| PC-21609 |
WK369
BCL6-BTB inhibitor
|
WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays. |
