| Cat. No. |
Product Name |
Information |
| PC-27911 |
WX-02-16
BAX inhibitor
|
WX-02-16 is an enantioselective covalent inhibitor of BAX, dose-dependently suppresses tBID-triggered, BAX-mediated mitochondrial cytochrome c release, shows covalent engagement of BAX Cys126, protects cells from BAX-dependent apoptosis in HCT116 cells and primary DRG neurons. |
| PC-27910 |
CBI-3
BAX inhibitor
|
CBI-3 (Covalent BAX inhibitor 3) is a covalent BAX inhibitor, protects cells from BAX-dependent apoptosis. |
| PC-27548 |
CYD0281
Bcl-2-BH4 antagonist
|
CYD0281 is a Bcl-2 BH4 domain antagonist, induces Bcl-2-dependent Bax activation, inhibits tumor angiogenesis and breast cancer tumor growth. |
| PC-27545 |
CYD-4-61
Bax activator
|
CYD-4-61 is a small molecule Bax activator, exhibits potent antiproliferative activity with IC50 of 0.07 uM against triple-negative breast cancer MDA-MB-231 and 0.06 uM against ER-positive breast cancer MCF-7 cell lines, respectively. |
| PC-27373 |
MIRO1 Reducer 3
MIRO1-BAX inhibitor
|
MIRO1 Reducer 3 (MR3, Miro1 Reducer) is first-in-class small molecule that allosterically disrupt mitochondrial Rho GTPase 1 (MIRO1)-BAX complex, binds C-GTPase domain of the MIRO1, blocks BAX activation and membrane destruction. |
| PC-27267 |
Guggulsterone
Bcl-2 inhibitor
|
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii, inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), inhibits the proliferation of HL60 and U937 cells with IC50 of 3.6-10.9 uM, also is a farnesoid X receptor (FXR) antagonist. |
| PC-27233 |
Gambogic Acid
Bcl-2 inhibitor, SHMT2 inhibitor
|
Gambogic Acid (Beta-Guttiferrin) is a natural product derived from Garcinia hanburyi Hook with anticancer properties, inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, also binds specifically to SHMT2 Cys241, inhibiting SHMT2 enzymatic activity and disrupting mitochondrial function. |
| PC-27103 |
BNIP3 antagonist peptide B-017
BNIP3 antagonist
|
B-017 (WVELHFFN) is a mitochondrial protective peptide antagonist of BCL-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), binds to both BNIP3 and BAX with KD of 700 nM and 303 nM respectively, preventing the direct activation of BAX and its insertion into mitochondrial outer membrane. |
| PC-26415 |
BAX activator 27c
BAX activator
|
BAX activator 27c is a selective small molecule BAX activator with binding IC50 of 0.3 uM in competitive FP binding assays, shows >40-fold selectivity over other antiapoptotic BCL-2 family proteins. |
| PC-26343 |
Nexatoclax
Bcl-2/xL inhibitor
|
Nexatoclax (LP-118) is a potent small molecule inhibitor of Bcl-2 and Bcl-xL (IC50=10.1 nM), more potent than venetoclax and with added advantage of selectively binding to Bcl-xL while minimizing the platelet toxicity. |
| PC-26239 |
Bfl-1 inhibitor 25
Bfl-1 inhibitor
|
Bfl-1 inhibitor 25 is a potent and irreversible cellular probe inhibitor of Bcl-2 family member Bfl-1 with FRET IC50 of 16 nM, inhibits SU-DHL-1 cell viability with EC50 of 0.21 uM. |
| PC-25524 |
YC137
BCL-2 inhibitor
|
YC137 is a specific small molecule inhibitor of Bcl-2 with Ki of 1.3 uM, with no affinity for Bcl-xL (Ki>100 uM), inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. |
