| Cat. No. |
Product Name |
Information |
| PC-49852 |
MI-238
Mcl-1 inhibitor
|
MI-238 (MI 238) is a potent and specific Mcl-1 inhibitor with Ki of 0.45 uM to human Mcl-1 protein in FP assays, disrupts the association of Mcl-1 with BH3-only proteins. |
| PC-49291 |
pBADS99 inhibitor NPB
pBAD Ser99 inhibitor
|
NPB (pBADS99 inhibitor NPB) is a small molecule that inhibits BCL-2-associated death promoter (BAD) phosphorylation specifically at Ser99 with IC50 of 0.41 M. |
| PC-38808 |
CCT369260
BCL6 degrader
|
CCT369260 is a highly potent, orally active BCL6 degrader with DC50 of 54 nM in cellular BCL6 degradation assays. |
| PC-73236 |
ZH07
Dual Mcl-1/Bfl-1 inhibitor
|
ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively. |
| PC-72944 |
BTSA1
BAX activator
|
BTSA1 (BAX Trigger Site Activator 1) is a potent, selective, orally bioavailable BAX trigger site activator, binds with high affinity (EC50=144 nM) and specificity to the N-terminal activation site. |
| PC-72943 |
BTSA1.2
BAX activator
|
BTSA1.2 is a potent, selective, orally bioavailable BAX activator, demonstrated increased binding to BAX (IC50=149 nM) compared to BTSA1 (IC50=247 nM). |
| PC-72541 |
BFL-1 inhibitor 4E14
BFL-1 inhibitor
|
4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction). |
| PC-72311 |
Lisaftoclax
BCL-2 inhibitor
|
Lisaftoclax (APG-2575) is a novel BCL-2 selective inhibitor with binding Ki of < 0.1/0.1 nM for Bcl-2/Bcl-XL, no binding affinity against BCL-W/MCL-1. |
| PC-72240 |
BAX inhibitor BAI1
BAX inhibitor
|
BAX inhibitor BAI1 (BAI1) is a small-molecule allosteric inhibitor of BAX, bind directly to BAX and inhibits tBID-induced BAX-mediated membrane permeabilization with IC50 of 3.4 uM. |
| PC-38265 |
EU-5346
Mcl-1 inhibitor
|
EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction. |
| PC-35716 |
BCL6 inhibitor 14
BCL6 inhibitor
|
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM.. |
| PC-35691 |
S64315
Mcl-1 inhibitor
|
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. |
