| Cat. No. |
Product Name |
Information |
| PC-73236 |
ZH07
Dual Mcl-1/Bfl-1 inhibitor
|
ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively. |
| PC-73235 |
ZH97
BFL-1 inhibitor
|
ZH97 is a selective and covalent small-molecule inhibitor of BFL-1 protein with binding Ki of 0.41 uM, >200-fold selectivity over MCL-1. |
| PC-73094 |
WEHI-9625
BAK inhibitor
|
WEHI-9625 (WEHI9625) is a small molecule selectively binds to VDAC2 and promotes its ability to inhibits apoptosis (EC50=69 nM) driven by murine BAK, selectively blocks murine BAK-mediated apoptosis. |
| PC-72944 |
BTSA1
BAX activator
|
BTSA1 (BAX Trigger Site Activator 1) is a potent, selective, orally bioavailable BAX trigger site activator, binds with high affinity (EC50=144 nM) and specificity to the N-terminal activation site. |
| PC-72943 |
BTSA1.2
BAX activator
|
BTSA1.2 is a potent, selective, orally bioavailable BAX activator, demonstrated increased binding to BAX (IC50=149 nM) compared to BTSA1 (IC50=247 nM). |
| PC-72541 |
BFL-1 inhibitor 4E14
BFL-1 inhibitor
|
4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction). |
| PC-72519 |
CCT369347
BCL-6 inhibitor
|
CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM. |
| PC-72311 |
Lisaftoclax
BCL-2 inhibitor
|
Lisaftoclax (APG-2575) is a novel BCL-2 selective inhibitor with binding Ki of < 0.1/0.1 nM for Bcl-2/Bcl-XL, no binding affinity against BCL-W/MCL-1. |
| PC-72240 |
BAX inhibitor BAI1
BAX inhibitor
|
BAX inhibitor BAI1 (BAI1) is a small-molecule allosteric inhibitor of BAX, bind directly to BAX and inhibits tBID-induced BAX-mediated membrane permeabilization with IC50 of 3.4 uM. |
| PC-38265 |
EU-5346
Mcl-1 inhibitor
|
EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction. |
| PC-36080 |
Jaceosidin
Bax activator
|
Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties, activates Bax and down-regulates Mcl-1 and c-FLIP expression. |
| PC-35716 |
BCL6 inhibitor 14
BCL6 inhibitor
|
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM.. |
