Cat. No. |
Product Name |
Information |
PC-42277 |
Navitoclax
BCL-2 inhibitor
|
Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w. |
PC-45490 |
UMI-77
Mcl-1 inhibitor
|
UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM. |
PC-45314 |
Gossypol acetic acid
BCL-2 inhibitor
|
Gossypol acetic acid ((±)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
PC-44439 |
AT-101
BCL-2 inhibitor
|
AT-101 ((R)-(-)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
PC-43513 |
Gossypol
BCL-2 inhibitor
|
Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes. |
PC-42244 |
S-63845
Mcl-1 inhibitor
|
S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM). |
PC-45901 |
ABT-737
BCL-2 inhibitor
|
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively. |
PC-22111 |
TUDCA
Bax inhibitor
|
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis. |
PC-22106 |
BAM7
Bax activator
|
BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death. BAM7 is selective for the BH3-binding site on BAX. |
PC-22105 |
CBI1
Bax inhibitor
|
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis. |
PC-21675 |
Sonrotoclax
Bcl-2 inhibitor
|
Sonrotoclax (BGB-11417) is a potent, selective and second-generation BCL2 inhibitor with IC50 of 0.014 nM and SPR KD value of 0.046 nM, overcomes BCL2 G101V mutation-induced venetoclax resistance. |
PC-21609 |
WK369
BCL6-BTB inhibitor
|
WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays. |