You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-Bcl-2

Request The Product List ofBcl-2 Bcl-2

Cat. No. Product Name Information
PC-42277

Navitoclax

BCL-2 inhibitor

Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
PC-45490

UMI-77

Mcl-1 inhibitor

UMI-77 is a potent and selective Mcl-1 inhibitor with Ki of 0.49 uM.
PC-45314

Gossypol acetic acid

BCL-2 inhibitor

Gossypol acetic acid ((±)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
PC-44439

AT-101

BCL-2 inhibitor

AT-101 ((R)-(-)-Gossypol acetic acid) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
PC-43513

Gossypol

BCL-2 inhibitor

Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
PC-42244

S-63845

Mcl-1 inhibitor

S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM).
PC-45901

ABT-737

BCL-2 inhibitor

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively.
PC-22111

TUDCA

Bax inhibitor

Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis.
PC-22106

BAM7

Bax activator

BAM7 is a selective Bax activator,, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death.
BAM7 is selective for the BH3-binding site on BAX.
PC-22105

CBI1

Bax inhibitor

Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis.
PC-21675

Sonrotoclax

Bcl-2 inhibitor

Sonrotoclax (BGB-11417) is a potent, selective and second-generation BCL2 inhibitor with IC50 of 0.014 nM and SPR KD value of 0.046 nM, overcomes BCL2 G101V mutation-induced venetoclax resistance.
PC-21609

WK369

BCL6-BTB inhibitor

WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com