| Cat. No. |
Product Name |
Information |
| PC-43048 |
A-1210477
Mcl-1 inhibitor
|
A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes, shows much weaker against Bcl-2 (Ki=132 nM) and Bcl-XL (Ki>660 nM). |
| PC-42836 |
TW-37
Bcl-2 inhibitor
|
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities. |
| PC-42826 |
HA14-1
Bcl-2 inhibitor
|
HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM, induces apoptosis of tumor cells. |
| PC-62743 |
MI-223
Mcl-1 inhibitor
|
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents. |
| PC-62553 |
Disarib
BCL2-BAK inhibitor
|
Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.). |
| PC-62551 |
Mcl-1-Puma inhibitor 8
Mcl-1-PUMA inhibitor
|
Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis. |
| PC-62538 |
BCL6-IN-8
BCL6 inhibitor
|
BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface. |
| PC-62306 |
A-385358
Bcl-XL inhibitor
|
A-385358 is a potent, selective, cell-permeable Bcl-XL inhibitor with Ki of 0.8 nM, displays >80-fold selectivity over Bcl-2 (Ki=64 nM). |
| PC-61991 |
BM-957
Bcl-2/Bcl-XL inhibitor
|
BM-957 (BM957) is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively. |
| PC-61989 |
S44563
Bcl-2/Bcl-XL inhibitor
|
S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively. |
| PC-61988 |
AZD 4320
Bcl-2/Bcl-XL inhibitor
|
AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of <1 nM. |
| PC-61404 |
AZD5991
Mcl-1 inhibitor
|
AZD5991 (AZD-5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity (SPR Kd=0.17 nM). |
