| Cat. No. |
Product Name |
Information |
| PC-72731 |
PSNCBAM-1
CB1 antagonist
|
PSNCBAM-1 is an allosteric antagonist of CB1 receptor with IC50 of 22.5 nM in Ca2+ assays, inhibits [3H]CP55,940 binding with EC50 of 167 nM. |
| PC-72730 |
RTICBM-189
CB1 NAM
|
RTICBM-189 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with pIC50 of 7.54 in Ca2+ assay, 5.29 in GTPγS assay. |
| PC-72729 |
RTICBM-229
CB1 NAM
|
RTICBM-229 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 169 nM in Ca2+ assay, 40 nM in GTPγS assay. |
| PC-72728 |
RTICBM-74
CB1 NAM
|
RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays. |
| PC-35625 |
XL-001
CB2 inverse agonist
|
XL-001 (XL001) is a novel specific CB2 inverse agonist with Ki of 0.5 nM. |
| PC-35592 |
AM9405
CB1/5-HT3 agonist
|
AM9405 (AM-9405, GAT-379) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively. |
| PC-35536 |
VCE-004.3
PPARγ/CB2 agonist
|
VCE-004.3 (VCE004.3) is a novel semi-synthetic cannabidiol derivative behaving as a dual PPARγ/CB2 agonist and CB1 receptor modulator, binds and activates PPARγ (IC50=3.5 uM) and CB2 receptors (pKi=6.69) and antagonizes CB1 receptor (pKi=5.61). |
| PC-35488 |
GAT100
CB1R modulator
|
GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM, does not exhibit inverse agonism. |
| PC-35485 |
GAT211
CB1R modulator
|
GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM. |
| PC-35125 |
PrNMI
CB1 agonist
|
PrNMI is a peripherally restricted cannabinoid 1 receptor (CB1R) agonist with Ki of 1.18 nM and EC50 of 182 nM (hCB1R). |
| PC-43469 |
WIN 55,212-2 mesylate
Cannabinoid receptor agonist
|
WIN 55,212-2 mesylate (WIN 55212-2) is a potent cannabinoid receptor agonist with Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. |
| PC-43465 |
Org 27569
CB1R modulator
|
Org 27569 is a potent, selective, allosteric modulator of cannabinoid CB1 receptor, significantly increases the binding of the CB1 receptor agonist [3H]CP 55,940 with pKb of 5.67. |
