| Cat. No. |
Product Name |
Information |
| PC-21712 |
PIPE-3297
KOR agonist
|
PIPE-3297 is a fully efficacious and selective kappa opioid receptor (KOR) agonist with functional GTPγS EC50 of 1.1 nM, Emax=91%, does not elicit β-arrestin-2 recruitment functional response. |
| PC-21574 |
ZYKR1
KOR agonist
|
ZYKR1 is a potent, and peripherally restricted kappa opioid receptor (KOR)-selective agonist with EC50 of 0.061 nM in cAMP assays, highly selective over the mu and delta opioid receptors (EC50>10 μM). |
| PC-20520 |
LY255582
Pan-opioid antagonist
|
LY255582 is a potent, pan-opioid antagonist with Ki value of for 0.4 nM, 5.2 nM and 2.0 nMmu, delta, and kappa receptors, respectively, decreases short- and long-term food intake in rats. |
| PC-20510 |
AT-076
Pan opioid antagonist
|
AT-076 (AT076) is the first potent small-molecule opioid pan antagonist with receptor binding Ki values of 1.75, 1.14, 1.67 and 19.6 nM for NOP, KOP, MOP, and DOP, respectively. |
| PC-47497 |
D-Ala2, D-Leu5-Enkephalin
|
An angiotensin II analog that is an agonist of AT1 angiotensin receptor.. |
| PC-45976 |
Alvimopan monohydrate
|
A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus. |
| PC-45978 |
Naltrexone hydrochloride
|
A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively. |
| PC-45960 |
Methylnaltrexone bromide
|
A peripherally-acting μ-opioid antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals.. |
