| Cat. No. |
Product Name |
Information |
| PC-60804 |
TRV0109101
MOR agonist
|
TRV0109101 is a selective, G protein-biased µ-opioid receptor (MOR) agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo. |
| PC-60803 |
TRV0109101 hydrochloride
MOR agonist
|
TRV0109101 hydrochloride is a selective, G protein-biased µ-opioid receptor agonist, does not promote the development of opioid-induced mechanical allodynia (OIMA) and rapidly reverses allodynia in vivo. |
| PC-60802 |
NKTR-181
MOR agonist
|
A novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold). |
| PC-60800 |
SB-612111 hydrochloride
NOP receptor antagonist
|
SB-612111 hydrochloride is a potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM. |
| PC-60799 |
AT-403
NOP agonist
|
AT-403 (AT403) is a potent, highly selective, nonpeptide NOP agonist with pEC50 of 9.45. |
| PC-60798 |
SCH 486757
ORL1 agonist
|
SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors. |
| PC-60797 |
SCH221510
NOP receptor agonist
|
SCH221510 is a potent, selective, orally active nociceptin opioid receptor (NOP) agonist with EC50 of 12 nM, Ki of 0.3 nM. |
| PC-60737 |
Eluxadoline
μ-opioid receptor agonist
|
A potent, selective, orally bioavailable µ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D).. |
| PC-60716 |
(±)-U-50488 hydrochloride
KOR antagonist
|
(±)-U-50488 hydrochloride is a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects. |
| PC-60715 |
(-)-U-50488 hydrochloride
KOR agonist
|
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist (Kd=2.2 nM) with no μ-opioid antagonist effects. |
| PC-45977 |
Alvimopan dihydrate
μ-opioid receptor antagonist
|
Alvimopan (ADL 8-2698, LY246736) dihydrate selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus. |
| PC-43423 |
Alvimopan
μ-opioid receptor antagonist
|
Alvimopan (LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus. |
