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Cat. No. Product Name Information
PC-35217

Cebranopadol

ORL1 agonist

Cebranopadol (GRT-6005, GRT6005) is a potent analgesic nociceptin/orphanin FQ peptide (NOP receptor, ORL1) and opioid receptor agonist with Ki/EC50 of 0.9/13 nM (human NOP receptor), 0.7/1.2 nM (mu-opioid receptor).
PC-43402

BAN ORL 24

ORL1 inhibitor

BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors.
PC-43352

ADL5859

DOR agonist

ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM.
PC-42356

PZM21

MOR agonist

PZM21 is a potent, selective Gi-biased μ-opioid-receptor (μOR, MOR) agonist with Ki/EC50 of 1.1/4.6 nM, has little to no detectable κOR/δOR agonist or nociceptin receptor agonist activity.
PC-63082

BMS-986187

δ-opioid receptor modulator

BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor (DOR) with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor.
PC-63080

BMS-986122

μ-opioid receptor modulator

BMS-986122 is a potent positive allosteric modulator of μ-opioid (MOR) receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells.
PC-62626

JTC-801

ORL1 agonist

JTC-801 is a highly potent, selective, orally active NOP receptor (ORL1) antagonist with Ki of 8.2 nM, shows 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively.
PC-62146

CYM51010

OPRM1-OPRD1 agonist

CYM51010 (ML335) is an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization with EC50 of 403 nM.
PC-62111

ML350

KOR antagonist

ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM.
PC-62110

Aticaprant

KOR antagonist

LY 2456302 (CERC-501, JSPA 0658, Aticaprant) is a potent, selective, short-acting antagonist of κ-opioid receptor (KOR) with Ki of 0.81 nM.
PC-62109

PF-04455242 hydrochloride

KOR antagonist

PF-04455242 hydrochloride is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively.
PC-62108

PF-04455242

KOR antagonist

PF-04455242 is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively.

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