| Cat. No. |
Product Name |
Information |
| PC-23203 |
ADL06
DOR agonist
|
ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin. |
| PC-23099 |
Icalcaprant
KOR antagonist
|
Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR. |
| PC-22956 |
Exoticin
6TM-μOR agonist
|
Exoticin is a selective agonist of 6TM μ opioid receptor (6TM-μOR) with Kd of 14 uM, induces 6TM-μOR-dependent signal transduction, shows broad-spectrum analgesic efficacy. |
| PC-22909 |
SalA-VS-08
KOR agonist
|
SalA-VS-08 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 68.5 nM and EC50 of 854 nM, shows G protein-biased KOR agonist activity. |
| PC-22908 |
SalA-VS-07
KOR agonist
|
SalA-VS-07 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 423 nM and EC50 of 181 nM, shows G protein-biased KOR agonist activity. |
| PC-22781 |
BMS-986124
MOR modulator
|
BMS-986124 is a small molecule silent allosteric modulator (SAM) of μ-opioid receptor (MOR), blocks the effects of the MOR positive allosteric modulator BMS-986122, but does not affect binding or activities of orthosteric MOR agonists such as endomorphin-I or DAMGO. |
| PC-22780 |
BMS-986122
MOR PAM
|
BMS-986122 is a positive allosteric modulator of μ-opioid receptor (MOR) with EC50 of 3.0 uM for increased β-arrestin recruitment by 20 nM endomorphin-I. |
| PC-22779 |
BMS-986121
MOR PAM
|
BMS-986121 is a positive allosteric modulator of μ-opioid receptor (MOR) with EC50 of 1 uM for increased β-arrestin recruitment by 20 nM endomorphin-I. |
| PC-22777 |
DAMGO
MOR agonist
|
DAMGO is a highly affinity, selective peptide agonist of mu-opioid receptor (MOR) with Kd of 3.46 nM. |
| PC-22776 |
BPRMU191
MOR modulator
|
BPRMU191 is a unique mu-opioid receptor (MOR) modulator with EC50 of 2.17 uM in FLIPR Ca2+ assay using CHO-K1/MOR/Gα15 cells, BPRMU191 binds to MOR in the presence of naloxone. |
| PC-22594 |
µOR inhibitor 368
δ-opioid receptor NAM
|
µOR inhibitor 368 (µOR NAM 368, Compound 368) is a potent, negative allosteric modulator (NMA)/inhibitor of µ-opioid receptor (µOR), significantly inhibits met-enkephalin-induced µOR activation of Gi, increases binding of 3H-naloxone with EC50 of 133 nM. |
| PC-22000 |
LY2444296
KOR inhibitor
|
LY2444296 is a potent, selective orally bioavailable, and short-acting kappa opioid receptor (KOPR) antagonist with Ki of 1 nM. |
