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Cat. No. Product Name Information
PC-45979

Naltrexone

Opioid receptor antagonist

Naltrexone is a potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
PC-45285

Meptazinol

MOR agonist

Meptazinol (IL-22811, WY-22811) is a partial µ-opioid receptor (MOR) agonist.
PC-42615

JDTic dihydrochloride

A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM.
PC-42614

JDTic

JDTic is a highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM.
PC-23203

ADL06

DOR agonist

ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin.
PC-23099

Icalcaprant

KOR antagonist

Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR.
PC-22956

Exoticin

6TM-μOR agonist

Exoticin is a selective agonist of 6TM μ opioid receptor (6TM-μOR) with Kd of 14 uM, induces 6TM-μOR-dependent signal transduction, shows broad-spectrum analgesic efficacy.
PC-22909

SalA-VS-08

KOR agonist

SalA-VS-08 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 68.5 nM and EC50 of 854 nM, shows G protein-biased KOR agonist activity.
PC-22908

SalA-VS-07

KOR agonist

SalA-VS-07 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 423 nM and EC50 of 181 nM, shows G protein-biased KOR agonist activity.
PC-22781

BMS-986124

MOR modulator

BMS-986124 is a small molecule silent allosteric modulator (SAM) of μ-opioid receptor (MOR), blocks the effects of the MOR positive allosteric modulator BMS-986122, but does not affect binding or activities of orthosteric MOR agonists such as endomorphin-I or DAMGO.
PC-22780

BMS-986122

MOR PAM

BMS-986122 is a positive allosteric modulator of μ-opioid receptor (MOR) with EC50 of 3.0 uM for increased β-arrestin recruitment by 20 nM endomorphin-I.
PC-22779

BMS-986121

MOR PAM

BMS-986121 is a positive allosteric modulator of μ-opioid receptor (MOR) with EC50 of 1 uM for increased β-arrestin recruitment by 20 nM endomorphin-I.

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