| Cat. No. |
Product Name |
Information |
| PC-43423 |
Alvimopan
μ-opioid receptor antagonist
|
Alvimopan (LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus. |
| PC-45979 |
Naltrexone
Opioid receptor antagonist
|
Naltrexone is a potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively. |
| PC-45285 |
Meptazinol
MOR agonist
|
Meptazinol (IL-22811, WY-22811) is a partial µ-opioid receptor (MOR) agonist. |
| PC-42615 |
JDTic dihydrochloride
|
A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM. |
| PC-42614 |
JDTic
|
JDTic is a highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM. |
| PC-23828 |
Difelikefalin
KOR agonist
|
Difelikefalin (CR-845; FE-202845) is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 1.16 nM, and binding Kd of 0.23 nM. |
| PC-23827 |
Anrikefon acetate
KOR agonist
|
Anrikefon (HSK21542) acetate is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 0.54 nM, and binding Kd of 0.068 nM. |
| PC-23826 |
HSK21542
KOR agonist
|
Anrikefon (HSK21542) is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 0.54 nM, and binding Kd of 0.068 nM. |
| PC-23788 |
Loperamide hydrochloride
mu-opioid receptor agonist
|
Loperamide hydrochloride (R-18553) is a potent, selective mu-opioid receptor (MOR) agonist, also is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor, shows anti-diarrheal effect. |
| PC-23693 |
DPDPE
DOR agonist
|
DPDPE is a potent, specific agonist of delta opioid receptor (DOR), shows anticonvulsant effects. |
| PC-23203 |
ADL06
DOR agonist
|
ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin. |
| PC-23099 |
Icalcaprant
KOR antagonist
|
Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR. |
