| Cat. No. |
Product Name |
Information |
| PC-20741 |
BLU-5937
P2X3 antagonist
|
BLU-5937 (Camlipixant, BLU5937) is a potent, selective and non-competitive P2X3 homotrimeric receptor antagonist with IC50 of 25 and 92 nM for human and rat P2X3 receptors, repsectively. |
| PC-72754 |
Eliapixant
P2X3 antagonist
|
Eliapixant (BAY 1817080) is a potent, selective P2X3 receptor antagonist with IC50 of 8 nM (hP2X3). |
| PC-72721 |
5-BDBD
P2X4 antagonist
|
5-BDBD is a potent and selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4-mediated currents in CHO cells with IC50 of 0.5 uM. |
| PC-72666 |
Sivopixant
P2X3 antagonist
|
Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM). |
| PC-72592 |
HEI3090
P2X7R activator
|
HEI3090 (HEI-3090) is a small-molecule P2RX7 activator (positive modulator) of purinergic P2RX7 receptor (P2X7R), enhances the P2RX7-mediated intracellular calcium concentration (Emax=250 nM). |
| PC-38015 |
Lu AF27139
|
Lu AF27139 is a potent, selective, CNS-penetrant P2X7 receptor antagonist, inhibits BzATP-induced currents in rat primary microglia with IC50 of 66 nM. |
| PC-62763 |
JNJ-55308942
|
JNJ-55308942 is a novel highly potent P2X7 antagonist with Ki of 1.0 and 6.5 nM for rat and human hP2X7, demonstrates significant activity against a panel of related P2X receptors (P2X1, P2X2, P2X3, P2X2/3, and P2X4. |
| PC-61575 |
CE-224535
P2X7 antagonist
|
CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP). |
| PC-61379 |
Gefapixant
P2X3 antagonist
|
Gefapixant (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer). |
| PC-70094 |
AZD-9056
P2X7 antagonist
|
AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45634 |
AZD-9056 hydrochloride
P2X7 antagonist
|
AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45846 |
A-740003
|
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively. |
