| Cat. No. |
Product Name |
Information |
| PC-25132 |
PPADS tetrasodium
P2X receptor antagonist
|
PPADS tetrasodiuma is a non-selective P2X receptor antagonist, inhibits recombinant P2X1, P2X12, P2X13, P2X15 with IC50 of 1-2.6 uM. |
| PC-21244 |
BX430
P2X4 antagonist
|
BX430 is a potent, highly selective and allosteric antagonist of P2X4 receptor channel with IC50 of 0.54 uM. |
| PC-20741 |
BLU-5937
P2X3 antagonist
|
BLU-5937 (Camlipixant, BLU5937) is a potent, selective and non-competitive P2X3 homotrimeric receptor antagonist with IC50 of 25 and 92 nM for human and rat P2X3 receptors, repsectively. |
| PC-20738 |
Filapixant
P2X3 antagonist
|
Filapixant (BAY1902607) is a potent, selective P2X3 receptor antagonist, shows a substantially higher in vitro selectivity for P2X3 over P2X2 when compared with Eliapixant (BAY1817080, Cat# PC-72754). |
| PC-49765 |
NF449
P2X1 antagonist
|
NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM. |
| PC-73112 |
BAY-1797
P2X4 antagonist
|
BAY-1797 (BAY1797) is a potent and selective P2X4 inhibitor/antagonist with IC50 of 211 nM (hP2X4). |
| PC-72754 |
Eliapixant
P2X3 antagonist
|
Eliapixant (BAY 1817080) is a potent, selective P2X3 receptor antagonist with IC50 of 8 nM (hP2X3). |
| PC-72721 |
5-BDBD
P2X4 antagonist
|
5-BDBD is a potent and selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4-mediated currents in CHO cells with IC50 of 0.5 uM. |
| PC-72666 |
Sivopixant
P2X3 antagonist
|
Sivopixant (S-600918) is a potent and selective P2X3 homotrimers antagonist with IC50 of 4.2 nM, 250-fold selectivity over P2X2/3 heterotrimer (IC50=1,100 nM). |
| PC-72592 |
HEI3090
P2X7R activator
|
HEI3090 (HEI-3090) is a small-molecule P2RX7 activator (positive modulator) of purinergic P2RX7 receptor (P2X7R), enhances the P2RX7-mediated intracellular calcium concentration (Emax=250 nM). |
| PC-38015 |
Lu AF27139
P2X7 antagonist
|
Lu AF27139 is a potent, selective, CNS-penetrant P2X7 receptor antagonist, inhibits BzATP-induced currents in rat primary microglia with IC50 of 66 nM. |
| PC-63496 |
AZ-2
ABCA1/apoE inducer
|
AZ-2 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity. |
