| Cat. No. |
Product Name |
Information |
| PC-24768 |
Topobexin
TOP2B inhibitor
|
Topobexin is a selective Topoisomerase IIβ (TOP2B) catalytic inhibitor with IC50 of 0.19 uM in DNA decatenation assays, 25-fold selective over TOP2A (IC50=4.8 uM). |
| PC-49305 |
Doxorubicin hydrochloride
Topo II inhibitor
|
Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II. |
| PC-38577 |
ARN-21934
Topo IIα inhibitor
|
ARN-21934 is a potent, highly selective human topoisomerase II α (Topo IIα) with IC50 of 2 μM for inhibition of DNA relaxation, 100-fold selectivity for topo IIα over Topo β. |
| PC-72675 |
HH-N25
Topo I inhibitor
|
HH-N25 is a a potent and selective topoisomerase I (TOP1) inhibitor with potent antiproliferative activities against a panel of human breast cancer cell lines (IC50=0.045-4.2 uM). |
| PC-72442 |
LMP744
Topo I inhibitor
|
LMP744 (MJ-III-65, NSC706744) is a small molecule TOP1 inhibitor antitumoral activity. |
| PC-72441 |
LMP517
TOP1/2 inhibitor
|
LMP517 (NSC 781517) is a non-camptothecin, dual TOP1 and TOP2 topoisomerase inhibitor. |
| PC-38245 |
Lapcin
Topoisomerase inhibitor
|
Lapcin is a potent dual topoisomerase I/II inhibitor with nM to pM IC50s against diverse cancer cell lines (Colon cancer HT29 cell IC50=0.516 nM). |
| PC-35639 |
STA-8666
|
STA-8666 (STA8666, STA-21-8666, PEN-866) is a novel HSP90 inhibitor/SN-38 drug conjugate (HDC), a potent topoisomerase I inhibitor and pharmacologically active metabolite of irinotecan, STA-8666 is cleaved by carboxylesterase (CES) to release SN-38. |
| PC-63536 |
Indotecan
Topo I inhibitor
|
Indotecan (LMP400) is an anticancer DNA Topoisomerase I (Top1) inhibitor, inhibits P388, HCT116, MCF-7 cell lines with IC50 of 300, 1200, 560 nM respectively. |
| PC-63535 |
Indimitecan
Topo I inhibitor
|
Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor, shows antiproliferative activities against various human cancer cell lines. |
| PC-63054 |
Idarubicin
Topo II inhibitor
|
Idarubicin (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells. |
| PC-62442 |
BNS-22
Topo II inhibitor
|
BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively. |
