| Cat. No. |
Product Name |
Information |
| PC-23023 |
Darifenacin
CHI3L1 inhibitor, M3 mAChR inhibitor
|
Darifenacin (UK-88525) is a potent, selective M3 muscarinic receptor antagonist with pKi of 8.9, also inhibits CHI3L1(Chitinase 3-like 1) and PDAC cell growth. |
| PC-22975 |
MK-7622
M1 mAChR PAM
|
MK-7622 is a potent, selective M1 muscarinic receptor-positive allosteric modulator. |
| PC-22961 |
VU6007496
M1 mAChR PAM
|
VU6007496 is a highly selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 228 nM (hM1), with minimal M1 agonism (EC50>10 μM). |
| PC-22893 |
VU6036864
M5 mAChR antagonist
|
VU6036864 is a highly potent, selective antagonist of muscarinic acetylcholine receptor mAChR subtype 5 (M5) with IC50 of 25 nM (hM5), >500 fold selectivity against M1-4 receptors. |
| PC-22795 |
PIPE-307
M1 mAChR antagonist
|
PIPE-307 is a potent, selective, orally bioavailable, brain-penetrant antagonist of M1 muscarinic acetylcholine receptor (M1R, M1 mAChR) with Ki of 4.6 nM in membranes overexpressing human M1R. |
| PC-22509 |
CHF-6550
MABA
|
CHF-6550 is a potent, dual acting muscarinic M3 antagonist and β2 agonist (MABA) with pKi values of 9.3 and 10.6 for M3 and β2 receptor, respectively. |
| PC-21369 |
VU 0365114
M5 mAChR PAM
|
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors. |
| PC-43517 |
Xanomeline oxalate
|
Xanomeline oxalate (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
| PC-43389 |
Biperiden hydrochloride
|
Biperiden Hcl (NSC 170950, NSC 84989) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.. |
| PC-61893 |
Fesoterodine fumarate
|
Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. |
| PC-61892 |
Fesoterodine maleate
|
Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. |
| PC-61761 |
Glycopyrronium bromide
|
Glycopyrronium bromide (CHF 5259) is a peripherally-acting quaternary ammonium antimuscarinic agent with little or no central nervous system activity. |
