| Cat. No. |
Product Name |
Information |
| PC-42101 |
AC-260584
mAChR M1 agonist
|
AC-260584 is a potent, selective, allosteric muscarinic M1 receptor agonist with pEC50 of 8.1, 7.6, 8.3 and 6.6 for WT M1, TM3 mutant W101A, L102A, and Y106A, repespectively. |
| PC-42096 |
DREADD agonist compound 21
hM3Dq agonist
|
DREADD agonist compound 21 (hM3Dq agonist) is a potent, selective human muscarinic acetylcholine M3 receptor (hM3Dq) full agonist with EC50 of 1.7 nM. |
| PC-45939 |
Cevimeline hydrochloride
mAChR M1 agonist
|
Cevimeline hydrochloride is a potent M1-selective muscarinic agonist. |
| PC-45185 |
Clozapine N-oxide
DREADD agonist, M4 mAChR agonist
|
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist, activates the DREADD receptor hM3Dq and hM4Di, a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor agonist with EC50 of 11 nM. |
| PC-43305 |
Batefenterol
MABA, OTUB1 inhibitor
|
Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively, also is a small-molecule inhibitor of deubiquitinase OTUB1 with SPR KD of 23.5 uM. |
| PC-27480 |
Murafenacin
mAChR M1 antagonist
|
Murafenacin is a potent, selective muscarinic acetylcholine M1 receptor antagonist. |
| PC-27303 |
Muscarinic antagonist KH-5
Muscarinic antagonist
|
KH-5 is a M1-preferring long-acting muscarinic antagonist (LAMA), functions as a dualsteric PAM antagonist at the M1 receptor, KH-5 behaves mainly as a competitive antagonist at M2 receptors. |
| PC-27274 |
VU6077564
mAChR M1 antagonist
|
VU6077564 is a peripherally restricted and selective mAChR M1 antagonist with IC50 of 31 nM (hM1), >300-fold selective over hM2. |
| PC-26730 |
VU0364572 TFA
M1 muscarinic receptor agonist
|
VU0364572 TFA is a potent, selective, orally active, allosteric agonist of M1 muscarinic receptor with an EC50 of 0.11 uM, shows neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's disease. |
| PC-26504 |
VU6052254
M1 PAM
|
VU6052254 is a potent, selective muscarinic acetylcholine receptor subtype 1 (M1) positive allosteric modulator (PAM) with EC50 of 59 nM. |
| PC-26253 |
VU6025733
M4 mAChR PAM
|
VU6025733 (AG06827) is a highly selective, orally bioavailable M4 muscarinic acetylcholine receptor (M4 mAChR) positive allosteric modulator (PAM) with EC50 of 23 nM and 55 nM for hM4 and rM4 respectively. |
| PC-25835 |
Xanomeline
M1 mAChR agonist
|
Xanomeline (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
