| Cat. No. |
Product Name |
Information |
| PC-72280 |
ASP8302
M3 PAM
|
ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor. |
| PC-38117 |
VU6007215
M4 mAChR PAM
|
VU6007215 is a potent, selective M4 positive allosteric modulator (PAM) with EC50 of 144 nM (hM4) and 295 nM (rM4). |
| PC-38116 |
VU6009048
M4 mAChR PAM
|
VU6009048 is a potent, selective M4 positive allosteric modulator (PAM) with EC50 of 85 nM (hM4) and 379 nM (rM4). |
| PC-35946 |
VU0467485
M4 mAChR PAM
|
VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4). |
| PC-35837 |
AZD6088
mAChR M1 agonist
|
AZD6088 (AZD-6088) is a potent and selective, orally bioavailable partial agonist of the M1 muscarinic receptor, reduces heat hyperalgesia in SNL rats with an EC50 of 46.6 nM.. |
| PC-35835 |
Spiropiperidine 1
M1 mAChR agonist
|
Spiropiperidine 1 (SPP1) is a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors. |
| PC-35747 |
VU6007477
M1 mAChR PAM
|
VU6007477 is a potent, selective, CNS penetrant M1 positive allosteric modulator (PAM) with EC50 of 230 nM, 93% ACh max with minimal M1 agonist activity. |
| PC-35626 |
GSK1034702
M1 mAChR agonist
|
GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5. |
| PC-35576 |
TAK-071
M1 mAChR PAM
|
TAK-071 (TAK071) is a potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells. |
| PC-35489 |
VU0467154
M4 mAChR PAM
|
VU0467154 (VU 0467154) is a potent, selective M4 mAChR positive allosteric modulator with EC50 of 17.7 nM. |
| PC-35486 |
VU6004256
M1 mAChR PAM
|
VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM). |
| PC-35482 |
PF-06827443
M1 mAChR PAM
|
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM. |
