| Cat. No. |
Product Name |
Information |
| PC-49312 |
CHF-6366
MABA
|
CHF-6366 is a novel potent muscarinic antagonist and β2 agonist (MABA) with pKi of 10.2 and 11.4, respectively. |
| PC-49070 |
VU0405645
M1 Receptor PAM
|
VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM. |
| PC-38388 |
Emraclidine
M4 mAChR PAM
|
Emraclidine (CVL-231) is a potent, selective positive allosteric modulator (PAM) of M4 muscarinic receptor subtype in development for schizophrenia. |
| PC-73364 |
VU6019650
M5 mAChR antagonist
|
VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4. |
| PC-72979 |
AZD8871
M3 β2 (MABA)
|
AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor. |
| PC-72662 |
VU6015241
mAChR4 antagonist
|
VU6015241 (VU 6015241) is a highly potent and selective antagonist of M4 muscarinic acetylcholine receptor (mAChR4) with IC50 of 71 nM. |
| PC-72655 |
HTL9936
M1 agonist
|
HTL9936 (HTL-9936) is a potent, selective M1-muscarinic acetylcholine (M1) receptor partial agonist with EC50 of 32 nM. |
| PC-72280 |
ASP8302
M3 PAM
|
ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor. |
| PC-38117 |
VU6007215
M4 mAChR PAM
|
VU6007215 is a potent, selective M4 positive allosteric modulator (PAM) with EC50 of 144 nM (hM4) and 295 nM (rM4). |
| PC-38116 |
VU6009048
M4 mAChR PAM
|
VU6009048 is a potent, selective M4 positive allosteric modulator (PAM) with EC50 of 85 nM (hM4) and 379 nM (rM4). |
| PC-35946 |
VU0467485
M4 mAChR PAM
|
VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4). |
| PC-35837 |
AZD6088
mAChR M1 agonist
|
AZD6088 (AZD-6088) is a potent and selective, orally bioavailable partial agonist of the M1 muscarinic receptor, reduces heat hyperalgesia in SNL rats with an EC50 of 46.6 nM.. |
