| Cat. No. |
Product Name |
Information |
| PC-20509 |
PIPE-359
M1 mAChR antagonist
|
PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R). |
| PC-20508 |
VU0415248
M1 mAChR antagonist
|
VU0415248 is a highly selective antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 0.4 uM and 0.18 uM for hM1R and rM1R, respectively. |
| PC-20104 |
Deschloroclozapine
DREADD agonist
|
Deschloroclozapine (DCZ) is a high-affinity and selective agonist for muscarinic-based DREADDs, shows nanomolar affinity for [3H]QNB-labeled hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
| PC-49312 |
CHF-6366
MABA
|
CHF-6366 is a novel potent muscarinic antagonist and β2 agonist (MABA) with pKi of 10.2 and 11.4, respectively. |
| PC-49070 |
VU0405645
M1 Receptor PAM
|
VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM. |
| PC-38388 |
Emraclidine
M4 mAChR PAM
|
Emraclidine (CVL-231) is a potent, selective positive allosteric modulator (PAM) of M4 muscarinic receptor subtype in development for schizophrenia. |
| PC-73364 |
VU6019650
M5 mAChR antagonist
|
VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4. |
| PC-72979 |
AZD8871
M3 β2 (MABA)
|
AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor. |
| PC-72783 |
VU6028418
M4 mAChR antagonist
|
VU6028418 (VU 6028418) is a potent, highly selective, orally bioavailable M4 mAChR antagonist with IC50 of 4.1 nM (hM4). |
| PC-72662 |
VU6015241
mAChR4 antagonist
|
VU6015241 (VU 6015241) is a highly potent and selective antagonist of M4 muscarinic acetylcholine receptor (mAChR4) with IC50 of 71 nM. |
| PC-72655 |
HTL9936
M1 mAChR agonist
|
HTL9936 (HTL-9936) is a potent, selective M1-muscarinic acetylcholine (M1) receptor partial agonist with EC50 of 32 nM. |
| PC-72280 |
ASP8302
M3 PAM
|
ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor. |
