| Cat. No. |
Product Name |
Information |
| PC-61789 |
PPBI
mAChR M1 agonist
|
PPBI is a potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively. |
| PC-61049 |
THRX-200495
MABA
|
THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor. |
| PC-61048 |
V0162
M3 mAChR antagonist
|
V0162 ((R)-Mequitazine) is a high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21. |
| PC-61047 |
AZD9164
M3 mAChR antagonist
|
AZD9164 is a highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0). |
| PC-61046 |
AZD8683
M3 mAChR antagonist
|
AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4. |
| PC-61043 |
Revefenacin
M3 mAChR antagonist
|
Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity. |
| PC-60736 |
VU 0255035
|
VU 0255035 is a potent, selective, CNS penetrant and competitive orthosteric antagonist of M1 mAChR with IC50 of 132 nM, >75-fold selectivity over M2-M5. |
| PC-60328 |
LY2033298
M4 mAChR PAM
|
LY2033298 (LY-2033298) is a potent, selective, positive allosteric modulator of muscarinic M4 receptors. |
| PC-60327 |
Iperoxo
mAChR agonist
|
Iperoxo is an extremely potent muscarinic receptor agonist with EC50 of 2.12 nM and 8.47 nM for M2 and M4, respectively. |
| PC-60326 |
LY-2119620
|
LY 2119620 is a potent, specific,positive allosteric modulator of muscarinic M2 and M4 receptors. |
| PC-45705 |
VU-0357017 hydrochloride
mAChR M1 agonist
|
VU-0357017 hydrochloride is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM. |
| PC-42101 |
AC-260584
mAChR M1 agonist
|
AC-260584 is a potent, selective, allosteric muscarinic M1 receptor agonist with pEC50 of 8.1, 7.6, 8.3 and 6.6 for WT M1, TM3 mutant W101A, L102A, and Y106A, repespectively. |
