| Cat. No. |
Product Name |
Information |
| PC-62160 |
VU 10010
M4 mAChR PAM
|
VU 10010 is a selective, allosteric potentiator of M4 mAChR (EC50=33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively), has no activity at other mAChR subtypes. |
| PC-62144 |
ML381 fumarate
M5 mAChR antagonist
|
ML381 (VU0488130) is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM). |
| PC-62143 |
ML381
M5 mAChR antagonist
|
ML381 (VU0488130) is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM). |
| PC-62140 |
VU0481443
M5 mAChR PAM
|
VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5. |
| PC-62118 |
VU 6008667
M5 mAChR PAM
|
VU 6008667 is a potent, highly selective M5 negative allosteric modulator with IC50 of 1.2 uM. |
| PC-61894 |
PF-3635659
M3 mAChR antagonist
|
PF-3635659 (PF-03635659) is a potent, very long dissociative half-life (slow off-rate, >1440 min) muscarinic M3 antagonist with Ki of 0.2 nM, shows potential for the treatment of chronic obstructive pulmonary disease (COPD). |
| PC-61891 |
Fesoterodine
|
Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. |
| PC-61789 |
PPBI
mAChR M1 agonist
|
PPBI is a potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively. |
| PC-61049 |
THRX-200495
MABA
|
THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor. |
| PC-61048 |
V0162
M3 mAChR antagonist
|
V0162 ((R)-Mequitazine) is a high affinity and long-acting antagonist of human M3 muscarinic acetylcholine receptor with pKi of 9.03-9.21. |
| PC-61047 |
AZD9164
M3 mAChR antagonist
|
AZD9164 is a highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0). |
| PC-61046 |
AZD8683
M3 mAChR antagonist
|
AZD8683 (AZD-8683) is a highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4. |
