| Cat. No. |
Product Name |
Information |
| PC-63443 |
LSN3172176
M1 mAChR agonist
|
LSN3172176 is a potent, selectiive M1 mAChR partial agonist (EC50 2.4-7.0nM, Emax 43%-73%), shows binding selectivity for M1 mAChRs (Kd=1.5 nM). |
| PC-63278 |
VU6009003
M4 mAChR PAM
|
VU6009003 is a potent, selective, CNS penetrant mAChR M4 positive allosteric modulator with EC50 of 197 nM and 437 nM for human and rat M4, respectively. |
| PC-43390 |
Biperiden
M1 mAChR antagonist
|
Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker. |
| PC-63038 |
THRX-198321
MABA
|
THRX-198321 is a bifunctional mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.69/10.05 for M1/M2 respectively, pEC50 of 9.25 for β2AR. |
| PC-62746 |
ML375
M5 mAChR NAM
|
ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM). |
| PC-62161 |
VU0152099
M4 mAChR PAM
|
VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM. |
| PC-62160 |
VU 10010
M4 mAChR PAM
|
VU 10010 is a selective, allosteric potentiator of M4 mAChR (EC50=33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively), has no activity at other mAChR subtypes. |
| PC-62143 |
ML381
M5 mAChR antagonist
|
ML381 (VU0488130) is a highly mAChR subtype selective M5 orthosteric antagonist with IC50/Ki of 450/340 nM for hM5, has no inhibitory activity on hM1-4 (IC50>30 uM). |
| PC-62140 |
VU0481443
M5 mAChR PAM
|
VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5. |
| PC-62118 |
VU 6008667
M5 mAChR PAM
|
VU 6008667 is a potent, highly selective M5 negative allosteric modulator with IC50 of 1.2 uM. |
| PC-61894 |
PF-3635659
M3 mAChR antagonist
|
PF-3635659 (PF-03635659) is a potent, very long dissociative half-life (slow off-rate, >1440 min) muscarinic M3 antagonist with Ki of 0.2 nM, shows potential for the treatment of chronic obstructive pulmonary disease (COPD). |
| PC-61891 |
Fesoterodine
|
Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. |
