| Cat. No. |
Product Name |
Information |
| PC-35477 |
PF-06764427
M1 mAChR PAM
|
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM. |
| PC-43505 |
VU0152100
M4 mAChR PAM
|
VU0152100 (VU152100) is a potent, selective positive allosteric modulator of M4 mAChR with EC50 of 0.38 uM for rat M4. |
| PC-63491 |
VU6007678
M5 mAChR PAM
|
VU6007678 is a potent, subtype selective, CNS penetrant M5 mAChR positive allosteric modulator (PAM) with EC50 of 41 nM. |
| PC-63463 |
VU0486846
M1 mAChR PAM
|
VU0486846 is a potent, highly selective M1 mAChR positive allosteric modulation (PAM) with EC50 of 0.31 uM. |
| PC-63443 |
LSN3172176
M1 mAChR agonist
|
LSN3172176 is a potent, selectiive M1 mAChR partial agonist (EC50 2.4-7.0nM, Emax 43%-73%), shows binding selectivity for M1 mAChRs (Kd=1.5 nM). |
| PC-63278 |
VU6009003
M4 mAChR PAM
|
VU6009003 is a potent, selective, CNS penetrant mAChR M4 positive allosteric modulator with EC50 of 197 nM and 437 nM for human and rat M4, respectively. |
| PC-43390 |
Biperiden
M1 mAChR antagonist
|
Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker. |
| PC-43031 |
mAChR-IN-1
mAChR antagonist
|
mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM.. |
| PC-42894 |
Umeclidinium bromide
mAChR antagonist
|
Umeclidinium bromide (GSK573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs. |
| PC-63038 |
THRX-198321
MABA
|
THRX-198321 is a bifunctional mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.69/10.05 for M1/M2 respectively, pEC50 of 9.25 for β2AR. |
| PC-62746 |
ML375
M5 mAChR NAM
|
ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM). |
| PC-62161 |
VU0152099
M4 mAChR PAM
|
VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM. |
