| Cat. No. |
Product Name |
Information |
| PC-42096 |
hM3Dq-agonist-21
M3 mAChR agonist
|
hM3Dq-agonist-21 is a potent, selective human muscarinic acetylcholine M3 receptor (hM3Dq) full agonist with EC50 of 1.7 nM. |
| PC-45939 |
Cevimeline hydrochloride
mAChR M1 agonist
|
Cevimeline hydrochloride is a potent M1-selective muscarinic agonist. |
| PC-43305 |
Batefenterol
MABA
|
Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively. |
| PC-22509 |
CHF-6550
MABA
|
CHF-6550 is a potent, dual acting muscarinic M3 antagonist and β2 agonist (MABA) with pKi values of 9.3 and 10.6 for M3 and β2 receptor, respectively. |
| PC-21369 |
VU 0365114
M5 mAChR PAM
|
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors. |
| PC-20509 |
PIPE-359
M1 mAChR antagonist
|
PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R). |
| PC-20508 |
VU0415248
M1 mAChR antagonist
|
VU0415248 is a highly selective antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 0.4 uM and 0.18 uM for hM1R and rM1R, respectively. |
| PC-20104 |
Deschloroclozapine
DREADD agonist
|
Deschloroclozapine (DCZ) is a high-affinity and selective agonist for muscarinic-based DREADDs, shows nanomolar affinity for [3H]QNB-labeled hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
| PC-72783 |
VU6028418
M4 mAChR antagonist
|
VU6028418 (VU 6028418) is a potent, highly selective, orally bioavailable M4 mAChR antagonist for the treatment of dystonia and other movement disorders. |
| PC-43517 |
Xanomeline oxalate
|
Xanomeline oxalate (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
| PC-43389 |
Biperiden hydrochloride
|
Biperiden Hcl (NSC 170950, NSC 84989) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.. |
| PC-43031 |
mAChR-IN-1
|
mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM.. |
