| Cat. No. |
Product Name |
Information |
| PC-23360 |
NB-360
BACE inhibitor
|
NB-360 is a potent, selective and brain penetrable dual BACE1/BACE2 inhibitor with IC50 of 5 nM/6 nM respectively. |
| PC-73095 |
AM-6494
BACE1 inhibitor
|
AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2. |
| PC-43534 |
AZD3839
BACE1 inhibitor
|
AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D. |
| PC-63380 |
LY3202626
BACE inhibitor
|
LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 239 nM. |
| PC-63377 |
AZ-4217
BACE1 inhibitor
|
AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells. |
| PC-63290 |
PF-06751979
BACE1 inhibitor
|
PF-06751979 is a potent, selective, brain penetrant BACE1 inhibitor with binding IC50 of 7.3, 27-fold selectivity over BACE2. |
| PC-43420 |
LY2886721
BACE1 inhibitor
|
LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases. |
| PC-61191 |
δ-secretase inhibitor 11
δ-secretase inhibitor
|
δ-secretase inhibitor 11 is a selective, orally bioactive and brain permeable δ-secretase (AEP, delta-secretase) inhibitor with IC50 of 700 nM. |
| PC-61044 |
RO5508887
BACE inhibitor
|
RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin. |
| PC-61042 |
TAK-070
BACE1 inhibitor
|
TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays. |
| PC-61041 |
AMG-8718
BACE1 inhibitor
|
AMG-8718 is a potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin. |
| PC-61040 |
VTP-37948
BACE1 inhibitor
|
VTP-37948 (BI 1181181) is a potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease. |
