| Cat. No. |
Product Name |
Information |
| PC-20410 |
Z-Tyr-Ala-CHN2
Cathepsin L inhibitor
|
Z-Tyr-Ala-CHN2 is a potent cathepsin L inhibitor with EC50 of <50 nM, has broad-spectrum coronavirus antiviral activity. |
| PC-20203 |
Dutacatib
Cathepsin K inhibitor
|
Dutacatib (AFG495) is potent, selective and non-covalent cathepsin K inhibitor with IC50 of 3-6 nM (human CatK), shows excellent selectivity profile versus human cathepsins L and S. |
| PC-49223 |
MK-1256
Cathepsin K inhibitor
|
MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F. |
| PC-38582 |
SID 26681509
Cathepsin L inhibitor
|
SID 26681509 is a potent, selective inhibitor of lysosome hydrolase cathepsin L with IC50 of 56 nM, displays no inhibitory activity at cathepsin G. |
| PC-73381 |
Calpeptin
Calpain inhibitor
|
Calpeptin is a potent, cell penetrating calpain inhibitor with ID50 of 40 nM for Calpain I in human platelets, also inhibits cathepsin K and is a potent and specific inhibitor of SARS-CoV-2 entry and some variants. |
| PC-73032 |
K777
Cathepsin L inhibitor
|
K777 (K11777, S-001, SLV213) is a highly potent, irreversible, covalent inhibitor of mammalian cathepsin L and other cysteine proteases of clan CA. |
| PC-72382 |
JNJ-39641160
Cathepsin S inhibitor
|
JNJ-39641160 (JNJ39641160) is a peripherally restricted, non-covalent, potent, selective, orally-available Cathepsin S (CatS) inhibitor with Ki of 38 nM (hCatS). |
| PC-38309 |
Z-Arg-Lys-AOMK
Cathepsin B inhibitor
|
Z-Arg-Lys-AOMK is a potent, selective, irreversible neutral pH 7.2 inhibitor of Cathepsin B with IC50 of 13 nM, >100-fold higher potent than at pH 4.6 (IC50=1,830 nM). |
| PC-38292 |
BI-1915
Cathepsin S inhibitor
|
BI-1915 (BI 1915) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 17 nM for in vitro use, no significant inhibition on Cathepsin L/K/B (IC50>10 uM). |
| PC-38291 |
BI-1124
Cathepsin S inhibitor
|
BI-1124 (BI 1124) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 7 nM, >40-fold selectivity over Cathepsin L/K/B. |
| PC-35163 |
MIV-711
Cathepsin K inhibitor
|
MIV-711 (MIV711, MV076159) is a potent, selective cathepsin K inhibitor with Ki of 0.98 nM, displays >1300-fold versus the other human cathepsins. |
| PC-35082 |
Cathepsin B inhibitor RC1
Cathepsin B inhibitor
|
Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes. |
