| Cat. No. |
Product Name |
Information |
| PC-70182 |
TX-1123
Src inhibitor
|
TX-1123 is a tyrphostin AG17 analog that exihibits potent Src kinase inhibitory activity with IC50 of 2.2 uM. |
| PC-70102 |
Damnacanthal
|
Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation. |
| PC-42475 |
Saracatinib
Src/Abl inhibitor
|
Saracatinib (AZD0530) is a potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30 nM for c-Src, Yes, Lck and Abl, respectively. |
| PC-42786 |
A-770041
Lck inhibitor
|
A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM. |
| PC-42537 |
KX2-391
Src/tubulin inhibitor
|
KX2-391(Tirbanibulin, KX 01, KX 2-391) is a highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor. |
| PC-20792 |
A-420983
Lck inhibitor
|
A-420983 is a potent, orally active inhibitor of Lck kinase with IC50 of 37 nM, inhibits whole blood IL-2 production with IC50 of 7 nM. |
| PC-49800 |
Toosendanin
Hck/Lyn inhibitor
|
Toosendanin is a small-molecule compound that blocks macrophage-mediated immunosuppression and activates T cells by inhibiting Hck and Lyn kinases, reprograms macrophages to enforce antitumor immunity in glioblastoma (GBM). |
| PC-38544 |
Squarunkin A
UNC119-cargo inhibitor
|
Squarunkin A is a small molecule UNC119-cargo interaction inhibitor, selectively inhibits the binding of the N-terminus of Src kinase to UNC119A with IC50 of 10 nM. |
| PC-72223 |
SM1–71
Multikinase inhibitor
|
SM1–71 is a multi-targeted acrylamide-modified inhibitor that covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC (IC50=4 nM), YES1, FGFR1 (IC50=54 nM), ZAK (MLTK), MAP3K1, LIMK1 and RSK2. |
| PC-36164 |
UNC119-Src interaction inhibitor 3
|
UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A. |
| PC-35738 |
Lck inhibitor C 8863
|
Lck inhibitor C 8863 (C8863, RK-24466, KIN 001-51) is a potent, selective Lck inhibitor, inhibits Lck (64-509) and LckCD isoforms with IC50 of <1 nM and < 2 nM. |
| PC-63476 |
UM-164
|
UM-164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β. |
