| Cat. No. |
Product Name |
Information |
| PC-42532 |
BMS-690514
EGFR/VEGFR inhibitor
|
BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively. |
| PC-45785 |
Tyrphostin AG 879
HER2 inhibitor, TrkA inhibitor
|
Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC. |
| PC-42546 |
AV-412 free base
EGFR inhibitor
|
AV-412 free base (MP412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-42545 |
AV-412
EGFR inhibitor
|
AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-45479 |
PD158780
EGFR inhibitor
|
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM. |
| PC-22389 |
AZ14133346
EGFR Ex20Ins inhibitor
|
AZ14133346 is a potent and selective inhibitor of EGFR Ex20Ins with enzyme IC50 of <3 nM and cell IC50 of 85 nM, 14-fold selective over wild-type EGFR (cell IC50=1200 nM). |
| PC-22307 |
Mefatinib
EGFR inhibitor
|
Mefatinib (Mifanertinib dimaleate, MET306, MET-306) is a potent, bioavailable, second-generation, irreversible dual inhibitor of EGFR/HER2 with IC50 of 0.4/11.7 nM, respectively. |
| PC-22088 |
Icotinib hydrochloride
EGFR inhibitor
|
Icotinib hydrochloride (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q. |
| PC-22087 |
Icotinib
EGFR inhibitor
|
Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q. |
| PC-21851 |
DDC4002
mutant EGFR inhibitor
|
DDC4002 is a potent, selective and allosteric EGFR inhibitor, shows selectivity against L858R/T790M/C797S EGFR mutants with IC50 of 39-50 nM, does not inhibit WT EGFR. |
| PC-21850 |
EAI001
mutant EGFR inhibitor
|
EAI001 is a potent, mutant-selectiveepidermal growth factor receptor (EGFR) allosteric inhibitor with IC50 value of 24 nM for EGFRL858R/T790M. |
| PC-21841 |
AG1478
EGFR inhibitor
|
AG1478 (Tyrphostin AG-1478) is a potent, selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. |
