| Cat. No. |
Product Name |
Information |
| PC-23314 |
BAY 2476568
EGFR Ex20Ins inhibitor
|
BAY 2476568 (BAY-598) is the first reversible, potent and selective inhibitor of EGFR exon 20 insertions with IC50 of 20 and 24 nM for V769_D770insASV (insASV) and D770_N771insSVD (insSVD), with a wide margin of selectivity versus WT EGFR. |
| PC-22758 |
MTX-531
EGFR/PI3K inhibitor
|
MTX-531 (MTX531) is a first-in-class, potent and selective inhibitor of EGFR and PI3K with IC50 of 15 nM and 6.4 nM (PI3Kα), respectively. |
| PC-22307 |
Mefatinib
EGFR inhibitor
|
Mefatinib (Mifanertinib dimaleate, MET306, MET-306) is a potent, bioavailable, second-generation, irreversible dual inhibitor of EGFR/HER2 with IC50 of 0.4/11.7 nM, respectively. |
| PC-21782 |
HSL119
HUNK inhibitor
|
HSL119 (HSL 119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays. |
| PC-21761 |
BI-4732
EGFR inhibitor
|
BI-4732 is a potent, highly BBB penetrant, fourth-generation EGFR inhibitor against EGFR activating mutations, including C797S. |
| PC-20781 |
Mubritinib
HER2 inhibitor
|
Mubritinib (TAK-165) is a potent inhibitor of human epidermal growth factor receptor 2 (HER2, ERBB2) tyrosine kinase with IC50 of 6 nM, also is a potent Complex I inhibitor with IC50 of 51 nM. |
| PC-20669 |
Zongertinib
HER2 inhibitor
|
Zongertinib (BI 1810631, BI-1810631) is a potent, selective HER2 inhibitor, binds to the TKD of HER2 while sparing wild-type EGFR. |
| PC-20174 |
ER121
EGFR inhibitor
|
ER121 (ER-121) is a potent, dual kinase inhibitor targeting both mutant EGFR and activated erbB2 with IC50 of 0.08/0.15 nM (EGFR C797S/EGFR WT, ATP=10 uM). |
| PC-20044 |
Mifanertinib
EGFR inhibitor
|
Mifanertinib (Mefatinib free base) is a potent selective EGFR and HER2 kinase inhibitor with potential for for treatment of cancer. |
| PC-49519 |
HCD3514
EGFR C797S inhibitor
|
HCD3514 is a novel potent, selective, fourth-generation EGFR inhibitor targeting C797S triple mutation, strongly inhibits EGFRL858R/T790M/C797S and EGFR19del/T790M/C797S mutations with IC50 of 1.0 and 2.0 nM, respectively. |
| PC-49395 |
TAS2940
pan-ERBB inhibitor
|
TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor with IC50 of 5.6 nM、2.1 nM and 1.0 nM for HER2、HER2 V777L and A775_G776insYVMA, respectively. |
| PC-49365 |
EGFR inhibitor 57
EGFR L858R inhibitor
|
EGFR inhibitor 57 is a novel potent, selective, allosteric fourth-generation EGFR L858R inhibitor, overcomes EGFRC797S-mediated resistance in NSCLC harboring the activating EGFRL858R mutation. |
