| Cat. No. |
Product Name |
Information |
| PC-38347 |
ASK120067
EGFR mutant inhibitor
|
ASK120067 (Limertinib) is a novel third-generation inhibitor of EGFR T790M (L858R/T790M IC50=0.3 nM, T790M IC50=0.5 nM), with selectivity over EGFR WT (IC50=6 nM). |
| PC-38346 |
TAS-121
EGFR mutant inhibitor
|
TAS-121 (TAS 121) is an orally available, potent, novel third-generation EGFR-TKI that selectively targets EGFR activating and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38345 |
Oritinib mesylate
mutant EGFR inhibitor
|
Oritinib mesylate (SH-1028) is an irreversible third-generation EGFR inhibitor, selectively and specifically inhibits EGFR active mutations and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38344 |
Oritinib
mutant EGFR inhibitor
|
Oritinib (SH-1028) is an irreversible third-generation EGFR inhibitor, selectively and specifically inhibits EGFR active mutations and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38343 |
Rezivertinib
EGFR inhibitor
|
Rezivertinib (BPI-7711) is a novel third-generation EGFR tyrosine kinase inhibitor selective for EGFR-sensitizing and T790M mutations, shows potential against T790M-mediated drug resistance. |
| PC-38342 |
Almonertinib
EGFR inhibitor
|
Aumolertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations with IC50 of 0.37 nM (T790M), 0.21 nM (del19/T790M), 0.29 nM(L858R/T790M), and 3.39 nM (EGFR WT). |
| PC-38341 |
Befotertinib
EGFR inhibitor
|
Befotertinib (D-0316) is an orally active, third-generation EGFR tyrosine kinase inhibitor that is selective for both EGFR-TKI sensitizing and T790M resistance mutations in NSCLC. |
| PC-73366 |
JBJ-09-063
EGFR mutant inhibitor
|
JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain. |
| PC-73295 |
DDC-03-024-01
EGFR mutant inhibitor
|
DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM. |
| PC-73154 |
Mobocertinib succinate
EGFR Ex20Ins inhibitor
|
Mobocertinib succinate (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73153 |
Mobocertinib
EGFR Ex20Ins inhibitor
|
Mobocertinib (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73140 |
BDTX-189
EGFR mutant inhibitor
|
BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants. |
