| Cat. No. |
Product Name |
Information |
| PC-72984 |
JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72903 |
BLU-945
mutant EGFR inhibitor
|
BLU-945 (ZL-2313, BLU945, BLU 945) is a potent, mutant-selective inhibitor of EGFR T790M/C797S and EGFR+/T790M mutations (IC50<1 nM). |
| PC-72416 |
EMI1
EGFR inhibitor, COPB2 binder
|
EMI1 (EGFR MaMTH Inhibitor 1, ChemBridge 5213777) is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S activating mutant inhibitor, inhibits viability of PC9 EGFR ex19del/T790M/C797S with EC50 of 115 nM, potently reducing the interaction of EGFR triple mutant with Shc1 in MaMTH-DS assays. |
| PC-72415 |
EMI66
COPB2 binder
|
EMI66 (EMI-66) is a small molecule that attenuates RTK expression and signalling and alters the electrophoretic mobility of Coatomer Protein Complex Beta 2 (COPB2, binding Kd=1.51 uM) in lung cancer cells. |
| PC-72379 |
AC3573
HER3 inhibitor
|
AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM. |
| PC-72266 |
SPH5030
HER2 mutant inhibitor
|
SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants. |
| PC-38187 |
JCN037
EGFR inhibitor
|
JCN037 (JCN 037, JGK037) is novel potent, brain-penetrant, noncovalent EGFR TKI with IC50 of 2.49 nM. |
| PC-38170 |
CH7233163
mutant EGFR inhibitor
|
CH7233163 is a novel potent, selective mutant EGFR-Del19/T790M/C797S inhibitor with IC50 of 0.28 nM in biochemical assays. |
| PC-38101 |
Sunvozertinib
EGFR inhibitor
|
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations (IC50=0.4-2.1 nM). |
| PC-38035 |
CNX2006
EGFR inhibitor
|
CNX2006 (CNX-2006) is a potent, covalent, mutant-selective EGFR inhibitor with IC50 of <20 nM, weak inhibition at wild-type EGFR. |
| PC-38032 |
TQB3804
EGFR C797S inhibitor
|
TQB3804 (EGFR-IN-7) is a selective, potent, 3rd generation EGFR C797S inhibitor with IC50 of 1.07 nM and 0.13 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively. |
| PC-38023 |
Tucatinib
ErbB-2 (HER2) inhibitor
|
Tucatinib (Irbinitinib, ONT-380, ARRY-380) is a potent, selective, reversible and ATP-competitive inhibitor of ErbB-2 (HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively. |
