| Cat. No. |
Product Name |
Information |
| PC-43354 |
Sapitinib
EGFR inhibitor
|
Sapitinib (AZD-8931, AZD8931) is a equipotent, reversible inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4. 3 and 4 nM (phosphorylation inhibition), respectively. |
| PC-43273 |
EGF816
mutant EGFR inhibitor
|
EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1 for EGFR (L858R/790M), respectively. |
| PC-42843 |
WZ8040
EGFR T790M inhibitor
|
WZ8040 is a potent, mutant-selective, irreversible EGFR T790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR. |
| PC-42841 |
WZ4002
mutant EGFR inhibitor
|
WZ4002 is a potent, mutant-selective, covalent EGFR inhibitor with IC50 of 2, 8, 3 and 2 nM for EGFR L858R, EGFR L858R/T790M, EGFR E746-A750 and EGFRE746-A750/T790M, respectively. |
| PC-42828 |
PD153035 hydrochloride
|
PD153035 (ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271) is a highly potent, specific, ATP-competitive EGFR inhibitor with IC50 of 0.025 nM. |
| PC-42823 |
Erlotinib mesylate
EGFR inhibitor
|
Erlotinib mesylate (CP-358774, OSI-774, NSC 718781) is a potent, selective inhibitor of EGFR with IC50 of 2 nM. |
| PC-42822 |
Erlotinib hydrochloride
EGFR inhibitor
|
Erlotinib hydrochloride (CP-358774; OSI-774; NSC 718781) is a potent, selective inhibitor of EGFR with IC50 of 2 nM. |
| PC-42819 |
WZ-3146
EGFR inhibitor
|
WZ-3146 is a potent, mutant-selective EGFR kinase inhibitor with IC50 of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746-A750, EGFRE746-A750/T790M and wt EGFR, respectively. |
| PC-42818 |
AG490
Multikinase inhibitor
|
AG-490 (Tyrphostin AG 490) is a multi-targeted tyrphostin family of tyrosine kinase inhibitor, inhibits EGF receptor tyrosine kinase with IC50 of 2 and 13.5 uM for EGFR and ErbB2, also inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways. |
| PC-63158 |
AZ5104
EGFR inhibitor
|
AZ 5104 is the active metabolite of AZD 9291 (Osimertinib), which is an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations (IC50=15-17 nM) that spares the wild-type form of the receptor (IC50=480 nM). |
| PC-62998 |
BIBU1361
EGFR inhibitor
|
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM). |
| PC-62121 |
Theliatinib
EGFR inhibitor
|
Theliatinib (HMPL309) is a highly selective, potent, ATP-competitive inhibitor of EGFR with IC50 of 3 nM/22 nM for EGFR/EGFRT790M/L858R mutant, respectively. |
