| Cat. No. |
Product Name |
Information |
| PC-72266 |
SPH5030
HER2 mutant inhibitor
|
SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants. |
| PC-72062 |
ErbB4 inhibitor Compound IIa
ErbB4 inhibitor
|
ErbB4 inhibitor Compound IIa is a first-in-class, potent, selective ErbB4 (HER4) inhibitor with IC50 of 17.7 nM. |
| PC-72061 |
ErbB4 inhibitor Compound Ik
ErbB4 inhibitor
|
ErbB4 inhibitor Compound Ik is a first-in-class, potent, selective ErbB4 (HER4) inhibitor with IC50 of 15.24 nM. |
| PC-72058 |
AL906
EGFR inhibitor
|
AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation). |
| PC-38187 |
JCN037
EGFR inhibitor
|
JCN037 (JCN 037, JGK037) is novel potent, brain-penetrant, noncovalent EGFR inhibitor with IC50 of 2.49 nM. |
| PC-38170 |
CH7233163
mutant EGFR inhibitor
|
CH7233163 is a novel potent, selective mutant EGFR-Del19/T790M/C797S inhibitor with IC50 of 0.28 nM in biochemical assays. |
| PC-38118 |
NSC81111
EGFR inhibitor
|
NSC81111 is a highly potent EGFR-TK inhibitor with IC50 of 0.15 nM. |
| PC-38101 |
Sunvozertinib
EGFR inhibitor
|
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations (IC50=0.4-2.1 nM). |
| PC-38035 |
CNX2006
EGFR inhibitor
|
CNX2006 (CNX-2006) is a potent, covalent, mutant-selective EGFR inhibitor with IC50 of <20 nM, weak inhibition at wild-type EGFR. |
| PC-38032 |
TQB3804
EGFR C797S inhibitor
|
TQB3804 (EGFR-IN-7) is a selective, potent, 3rd generation EGFR C797S inhibitor with IC50 of 1.07 nM and 0.13 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively. |
| PC-38023 |
Tucatinib
HER2 inhibitor
|
Tucatinib (Irbinitinib, ONT-380, ARRY-380) is a potent, selective, reversible and ATP-competitive inhibitor of ErbB-2 (HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively. |
| PC-36109 |
TAS0728
|
TAS0728 (TAS-0728, TAS 0728) is a potent, selective, covalent, orally available inhibitor of HER2 kinase with IC50 of 36 nM in in vitro kinase assays. |
