| Cat. No. |
Product Name |
Information |
| PC-38101 |
Sunvozertinib
EGFR inhibitor
|
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations (IC50=0.4-2.1 nM). |
| PC-38035 |
CNX2006
EGFR inhibitor
|
CNX2006 (CNX-2006) is a potent, covalent, mutant-selective EGFR inhibitor with IC50 of <20 nM, weak inhibition at wild-type EGFR. |
| PC-38032 |
TQB3804
EGFR C797S inhibitor
|
TQB3804 (EGFR-IN-7) is a selective, potent, 3rd generation EGFR C797S inhibitor with IC50 of 1.07 nM and 0.13 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively. |
| PC-38023 |
Tucatinib
HER2 inhibitor
|
Tucatinib (Irbinitinib, ONT-380, ARRY-380) is a potent, selective, reversible and ATP-competitive inhibitor of ErbB-2 (HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively. |
| PC-36109 |
TAS0728
|
TAS0728 (TAS-0728, TAS 0728) is a potent, selective, covalent, orally available inhibitor of HER2 kinase with IC50 of 36 nM in in vitro kinase assays. |
| PC-35996 |
NS-062
EGFR C797S inhibitor
|
NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR. |
| PC-35826 |
JND3229
EGFR C797S inhibitor
|
JND3229 (JND-3229) is a novel highly potent, reversible EGFR C797S mutant inhibitor, potently inhibits the kinase activities of EGFRL858R/T790M and EGFRL858R/T790M/C797 with IC50 of 5.8 nM and 30.5 nM, respectively. |
| PC-35752 |
TX2-121-1
ErbB3 inhibitor
|
TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor. |
| PC-35641 |
Furmonertinib mesylate
EGFR inhibitor
|
Furmonertinib mesylate (AST-2818, Alflutinib mesylate) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation. |
| PC-35640 |
Alflutinib
EGFR inhibitor
|
Alflutinib (Furmonertinib, AST-2818) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation. |
| PC-35374 |
EGFR-HER2 Ex20Ins inhibitor 1a
EGFR/HER2 inhibitor
|
EGFR-HER2 Ex20Ins inhibitor 1a is a highly potent, broadly effective EGFR and HER2 Exon 20 insertion mutant inhibitor with biochemical IC50 of <0.5 nM (wtEGFR, 100 uM ATP). |
| PC-35261 |
mutant EGFR inhibitor B30
mutant EGFR inhibitor
|
mutant EGFR inhibitor B30 is a potent, selective, next-generation EGFR mutants inhibitor with IC50 of 1.1 and 7.2 nM for EGFRL858R and EGFRL858R/T790M/C797S, respectively. |
