| Cat. No. |
Product Name |
Information |
| PC-38343 |
Rezivertinib
EGFR inhibitor
|
Rezivertinib (BPI-7711) is a novel third-generation EGFR tyrosine kinase inhibitor selective for EGFR-sensitizing and T790M mutations, shows potential against T790M-mediated drug resistance. |
| PC-38342 |
Almonertinib
EGFR inhibitor
|
Aumolertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations with IC50 of 0.37 nM (T790M), 0.21 nM (del19/T790M), 0.29 nM(L858R/T790M), and 3.39 nM (EGFR WT). |
| PC-38341 |
Befotertinib
EGFR inhibitor
|
Befotertinib (D-0316) is an orally active, third-generation EGFR tyrosine kinase inhibitor that is selective for both EGFR-TKI sensitizing and T790M resistance mutations in NSCLC. |
| PC-73295 |
DDC-03-024-01
EGFR mutant inhibitor
|
DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM. |
| PC-73154 |
Mobocertinib succinate
EGFR mutant inhibitor
|
Mobocertinib succinate (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-72058 |
AL906
EGFR inhibitor
|
AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation). |
| PC-38118 |
NSC81111
|
NSC81111 is a highly potent EGFR-TK inhibitor with IC50 of 0.15 nM. |
| PC-35374 |
EGFR-HER2 Ex20Ins inhibitor 1a
|
EGFR-HER2 Ex20Ins inhibitor 1a is a highly potent, broadly effective EGFR and HER2 Exon 20 insertion mutant inhibitor with biochemical IC50 of <0.5 nM (wtEGFR, 100 uM ATP). |
| PC-35261 |
mutant EGFR inhibitor B30
|
mutant EGFR inhibitor B30 is a potent, selective, next-generation EGFR mutants inhibitor with IC50 of 1.1 and 7.2 nM for EGFRL858R and EGFRL858R/T790M/C797S, respectively. |
| PC-43274 |
EGF816 mesylate
|
EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively. |
| PC-42825 |
BMS-599626 hydrochloride
|
BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM. |
| PC-62999 |
BIBU1361 dihydrochloride
|
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM). |
