| Cat. No. |
Product Name |
Information |
| PC-42158 |
NVP-AEE788
EGFR inhibitor
|
NVP-AEE788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively. |
| PC-42640 |
Varlitinib
|
Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2. |
| PC-45549 |
AZD3759
EGFR inhibitor
|
AZD3759 (Zorifertinib) is a potent, orally active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR). |
| PC-42087 |
EAI-045
EGFR inhibitor
|
EAI-045 (EAI045) is a potent, mutant-selective allosteric EGFR inhibitor with IC50 of 3 nM for double mutant L858R/T790M in biochemical assays at 1 mM ATP. |
| PC-42553 |
Canertinib dihydrochloride
pan-ErbB inhibitor
|
Canertinib dihydrochloride (CI-1033, PD183805) is a potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay. |
| PC-44667 |
CO-1686 hydrobromide
EGFR inhibitor
|
Rociletinib (CO-1686) hydrobromide is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M. |
| PC-44666 |
CO-1686
EGFR inhibitor
|
Rociletinib (CO-1686, AVL-301, CNX-419) is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M. |
| PC-45813 |
Neratinib
HER2/EGFR inhibitor
|
Neratinib (HKI-272) is a potent, highly selective, irreversible HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays. |
| PC-42532 |
BMS-690514
EGFR/VEGFR inhibitor
|
BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively. |
| PC-45785 |
Tyrphostin AG 879
HER2 inhibitor, TrkA inhibitor
|
Tyrphostin AG 879 (AG879) potent HER2/ErbB2 inhibitor with IC50 of 1 uM, also selecitvely inhibits TrKA phosphorylation with IC50 of 10 uM, but not TrKB and TrKC. |
| PC-42386 |
RG13022
EGFR inhibitor
|
RG13022 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 5 uM in cell-free assays. |
| PC-42383 |
RG14620
EGFR inhibitor
|
RG14620 is a potent EGFR inhibitor that inhibits EGFR autophosphorylation with IC50 of 4 uM in cell-free assays. |
