| Cat. No. |
Product Name |
Information |
| PC-44706 |
AZD-9291
mutant EGFR inhibitor
|
Osimertinib (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively. |
| PC-45812 |
Pelitinib
EGFR inhibitor
|
Pelitinib (EKB-569, WAY-EKB 569) is a potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM. |
| PC-45891 |
Gefitinib
EGFR inhibitor
|
Gefitinib (ZD-1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM. |
| PC-45893 |
Erlotinib
EGFR inhibitor
|
Erlotinib (OSI-744; R-1415; CP-358774) is a potent, selective inhibitor of EGFR with IC50 of 2 nM. |
| PC-42486 |
BMS-599626
|
BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM. |
| PC-42158 |
AEE-788
EGFR inhibitor
|
AEE-788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively. |
| PC-42640 |
Varlitinib
|
Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2. |
| PC-45549 |
AZD3759
EGFR inhibitor
|
AZD3759 (Zorifertinib) is a potent, orally active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR). |
| PC-42087 |
EAI-045
EGFR inhibitor
|
EAI-045 (EAI045) is a potent, mutant-selective allosteric EGFR inhibitor with IC50 of 3 nM for double mutant L858R/T790M in biochemical assays at 1 mM ATP. |
| PC-42553 |
Canertinib dihydrochloride
pan-ErbB inhibitor
|
Canertinib dihydrochloride (CI-1033, PD183805) is a potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay. |
| PC-44666 |
CO-1686
EGFR inhibitor
|
Rociletinib (CO1686, AVL-301, CNX-419) is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M. |
| PC-45813 |
Neratinib
EGFR inhibitor
|
Neratinib (HKI-272) is a potent, highly selective, irreversible HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays. |
