| Cat. No. |
Product Name |
Information |
| PC-45894 |
Lapatinib
EGFR inhibitor
|
Lapatinib (GW 572016) is a reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. |
| PC-45997 |
AZD-9291 dimesylate
mutant EGFR inhibitor
|
Osimertinib dimesylate (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively. |
| PC-44707 |
AZD-9291 mesylate
mutant EGFR inhibitor
|
Osimertinib mesylate (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Osimertinib shows weak activity against wt EGFR (IC50=184 nM). |
| PC-44706 |
AZD-9291
mutant EGFR inhibitor
|
Osimertinib (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively. |
| PC-45812 |
Pelitinib
EGFR inhibitor
|
Pelitinib (EKB-569, WAY-EKB 569) is a potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM. |
| PC-45892 |
Gefitinib hydrochloride
EGFR inhibitor
|
Gefitinib hydrochloride (ZD1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM. |
| PC-45891 |
Gefitinib
EGFR inhibitor
|
Gefitinib (ZD1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM. |
| PC-45893 |
Erlotinib
EGFR inhibitor
|
Erlotinib (OSI-744; R-1415; CP-358774) is a potent, selective inhibitor of EGFR with IC50 of 2 nM. |
| PC-42486 |
BMS-599626
|
BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM. |
| PC-42158 |
NVP-AEE788
EGFR inhibitor
|
NVP-AEE788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively. |
| PC-42640 |
Varlitinib
|
Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2. |
| PC-45549 |
AZD3759
EGFR inhibitor
|
AZD3759 (Zorifertinib) is a potent, orally active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR). |
