| Cat. No. |
Product Name |
Information |
| PC-21566 |
BDTX-1535
EGFR inhibitor
|
BDTX-1535 is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC. |
| PC-21465 |
BI-8128
EGFR inhibitor
|
BI-8128 is a potent, selective, reversible and orally bioavailable fourth generation EGFR inhibitor, potently inhibits oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C797S. |
| PC-21322 |
STX-721
EGFR inhibitor
|
STX-721 is a potent, selective, next-generation, orally active inhibitor of EGFR exon 20 insertion mutations. |
| PC-21316 |
EGFR inhibitor 9
EGFR inhibitor
|
EGFR inhibitor 9 is a potent, selective, brain-penetrant and orally bioavailable EGFR inhibitor, exhibits potent activity in osimertinib-resistant cell lines bearing L858R/C797S and exon19del/C797S EGFR resistance mutations. |
| PC-21212 |
MTX-241F
EGFR inhibitor
|
MTX-241F (MTX241F) is a potent, highly selective and brain-penetrant inhibitor of EGFR, PI3K and DNA-PK with IC50 of 3 nM, 87 nM (PI3Kα) and 5.5 nM, respectively. |
| PC-20905 |
SDT-011
EGFR-mAb inhibitor
|
SDT-011 (SDT011) is a small molecule that effectively blocks the binding of anti-EGFR monoclonal antibodies to EGFR, blocks cetuximab-EGFR binding by 62% at 10 uM, binds to EGFR with Kd of 1.7 nM in MST assays. |
| PC-20818 |
HNPMI
EGFR inhibitor
|
HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers. |
| PC-20781 |
Mubritinib
HER2 inhibitor
|
Mubritinib (TAK-165) is a potent inhibitor of human epidermal growth factor receptor 2 (HER2, ERBB2) tyrosine kinase with IC50 of 6 nM, also is a potent Complex I inhibitor with IC50 of 51 nM. |
| PC-20174 |
ER121
mutant EGFR inhibitor
|
ER121 (ER-121) is a potent, dual kinase inhibitor targeting both mutant EGFR and activated erbB2 with IC50 of 0.08/0.15 nM (EGFR C797S/EGFR WT, ATP=10 uM). |
| PC-49395 |
TAS2940
pan-ERBB inhibitor
|
TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor. |
| PC-38733 |
HKI-357
EGFR inhibitor
|
HKI-357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR with IC50 values of 33 and 34 nM respectively. |
| PC-38348 |
LS‐106
EGFR mutant inhibitor
|
LS-106 is a novel, fourth‐generation EGFR inhibitor against C797S mutation, targeting both EGFR19del/T790M/C797S and EGFRL858/T790M/C797S with selectivity over EGFRwt. |
