| Cat. No. |
Product Name |
Information |
| PC-43486 |
XL-647
EGFR inhibitor
|
XL-647 (Tesevatinib, EXEL-7647, KD-019) is a novel spectrum-selective kinase inhibitor that potently inhibits the EGFR, ErbB2, KDR and EphB4 with IC50 of 0.3, 16, 1.5 and 1.4 nM, respectively. |
| PC-63499 |
TAS6417
EGFR Ex20Ins inhibitor
|
Zipalertinib (TAS6417, CLN-081) is a novel potent, selective inhibitor of EGFR exon 20 insertion mutations with IC50 of 1.1-8.0 nM, >100-fold selectivity over WT EGFR. |
| PC-43452 |
Dacomitinib
EGFR inhibitor
|
Dacomitinib (PF-00299804, PF-299804) is a potent, irreversible, orally active pan-ErbB receptor tyrosine kinase inhibitor with IC50 of 6, 45.7 and 73.7 for EGFR, ERBB2 and ERBB4, respectively. |
| PC-43436 |
OSI-420
EGFR inhibitor
|
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor for treatment of NSCLC.. |
| PC-63474 |
Simotinib
EGFR inhibitor
|
Simotinib (SIM-6802) is a novel potent, selective and orally bioavailable EGFR inhibitor with IC50 of 19.9 nM. |
| PC-63309 |
Epertinib
EGFR/HER2 inhibitor
|
Epertinib (S-222611) is a novel potent, orally active, reversible EGFR and HER2 inhibitor with IC50 of 1.48, 7.15 and 2.49 nM for EGFR, HER2 and HER4, respectively. |
| PC-43354 |
Sapitinib
EGFR inhibitor
|
Sapitinib (AZD-8931, AZD8931) is a equipotent, reversible inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4. 3 and 4 nM (phosphorylation inhibition), respectively. |
| PC-43274 |
EGF816 mesylate
mutant EGFR inhibitor
|
EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1, respectively. |
| PC-43273 |
EGF816
mutant EGFR inhibitor
|
EGF816 (Nazartinib) is a potent, irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min-1 for EGFR (L858R/790M), respectively. |
| PC-42843 |
WZ8040
EGFR T790M inhibitor
|
WZ8040 is a potent, mutant-selective, irreversible EGFR T790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR. |
| PC-42841 |
WZ4002
mutant EGFR inhibitor
|
WZ4002 is a potent, mutant-selective, covalent EGFR inhibitor with IC50 of 2, 8, 3 and 2 nM for EGFR L858R, EGFR L858R/T790M, EGFR E746-A750 and EGFRE746-A750/T790M, respectively. |
| PC-42828 |
PD153035 hydrochloride
|
PD153035 (ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271) is a highly potent, specific, ATP-competitive EGFR inhibitor with IC50 of 0.025 nM. |
