| Cat. No. |
Product Name |
Information |
| PC-42546 |
AV-412 free base
EGFR inhibitor
|
AV-412 free base (MP412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-42545 |
AV-412
EGFR inhibitor
|
AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-45479 |
PD158780
EGFR inhibitor
|
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM. |
| PC-45995 |
Mutated EGFR-IN-1
EGFR inhibitor
|
Mutated EGFR-IN-1 is an analogue of AZD9291 that is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. |
| PC-24172 |
YK-029A
mutant EGFR inhibitor
|
Pruvonertinib (YK-029A) is potent, wild-type sparing and mutant-selective inhibitor of EGFR T790 M and exon 20 insertion mutations with IC50 of 0.37 nM (EGFR L858R/T790 M), 29-fold selective over EGFR wt. |
| PC-24169 |
Perzebertinib
HER2 inhibitor
|
Perzebertinib (ZN-1041, ZN-A-1041) is a potent, selective BBB penetrable HER2 tyrosine kinase inhibitor. |
| PC-24132 |
Enozertinib
EGFR inhibitor
|
Enozertinib is a potent EGFR mutants inhibitor. |
| PC-24129 |
Emupertinib
EGFR inhibitor
|
Emupertinib is a potent EGFR inhibitor with IC50 values of <0.3 nM, 0.52 nM, 0.5 nM, 0.69 nM and 0.92 nM for EGFR (d746-750/T790M/C779S), EGFR (L858R/T790M/C797S), EGFR (d746-750/C797S), EGFR (L858R/C797S), and EGFR (wild-type), respectively. |
| PC-24110 |
Andamertinib
EGFR inhibitor
|
Andamertinib (PLB1004, PLB-1004) is a potent, selective and irreversible inhibitor of EGFR exon 20 insertion mutations with IC50 values ranging from 25.67-316.6 nM. |
| PC-24040 |
DA-0157
EGFR/ALK inhibitor
|
DA-0157 (DAJH-1050766) is a potent, dual inhibitor targeting EGFR C797S mutation, ALK-positive, and EGFR/ALK co-mutations with IC50 of 6.9 nM, 5.5 nM and 7.4 nM for EGFRDel19/T790M/C797S, ALK-WT and ALK-L1196M in Ba/F3 cell assays, respectively. |
| PC-23954 |
AZ14245445
EGFR Ex20Ins inhibitor
|
AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays. |
| PC-23953 |
AZ14240475
EGFR Ex20Ins inhibitor
|
AZ14240475 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.6 in cellular SVD, (EGFR D770_N771insSVD) assays. |
