| Cat. No. |
Product Name |
Information |
| PC-38342 |
Almonertinib
EGFR inhibitor
|
Aumolertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations with IC50 of 0.37 nM (T790M), 0.21 nM (del19/T790M), 0.29 nM(L858R/T790M), and 3.39 nM (EGFR WT). |
| PC-38341 |
Befotertinib
EGFR inhibitor
|
Befotertinib (D-0316) is an orally active, third-generation EGFR tyrosine kinase inhibitor that is selective for both EGFR-TKI sensitizing and T790M resistance mutations in NSCLC. |
| PC-73366 |
JBJ-09-063
EGFR mutant inhibitor
|
JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain. |
| PC-73295 |
DDC-03-024-01
EGFR mutant inhibitor
|
DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM. |
| PC-73154 |
Mobocertinib succinate
EGFR Ex20Ins inhibitor
|
Mobocertinib succinate (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73153 |
Mobocertinib
EGFR Ex20Ins inhibitor
|
Mobocertinib (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73140 |
BDTX-189
EGFR mutant inhibitor
|
BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants. |
| PC-73104 |
BI-4020
EGFR mutant inhibitor
|
BI-4020 (BI 4020) is a potent, next generation, wt-sparing inhibitor of EGFR mutant T790M and/or C797S, and EGFRdel19 T790M C797S (0.2 nM). |
| PC-73088 |
DBPR112
EGFR mutant inhibitor
|
Gozanertinib (DBPR112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations. |
| PC-72985 |
(Rac)-JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
(Rac)-JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72984 |
JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72903 |
BLU-945
mutant EGFR inhibitor
|
BLU-945 (ZL-2313, BLU945, BLU 945) is a potent, mutant-selective inhibitor of EGFR T790M/C797S and EGFR+/T790M mutations (IC50<1 nM). |
