| Cat. No. |
Product Name |
Information |
| PC-73104 |
BI-4020
EGFR mutant inhibitor
|
BI-4020 (BI 4020) is a potent, next generation, wt-sparing inhibitor of EGFR mutant T790M and/or C797S, and EGFRdel19 T790M C797S (0.2 nM). |
| PC-73088 |
DBPR112
EGFR mutant inhibitor
|
Gozanertinib (DBPR112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations. |
| PC-72985 |
(Rac)-JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
(Rac)-JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72984 |
JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72903 |
BLU-945
mutant EGFR inhibitor
|
BLU-945 (ZL-2313, BLU945, BLU 945) is a potent, mutant-selective inhibitor of EGFR T790M/C797S and EGFR+/T790M mutations (IC50<1 nM). |
| PC-72416 |
EMI1
EGFR inhibitor, COPB2 binder
|
EMI1 (EGFR MaMTH Inhibitor 1, ChemBridge 5213777) is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S activating mutant inhibitor, inhibits viability of PC9 EGFR ex19del/T790M/C797S with EC50 of 115 nM, potently reducing the interaction of EGFR triple mutant with Shc1 in MaMTH-DS assays. |
| PC-72415 |
EMI66
COPB2 binder
|
EMI66 (EMI-66) is a small molecule that attenuates RTK expression and signalling and alters the electrophoretic mobility of Coatomer Protein Complex Beta 2 (COPB2, binding Kd=1.51 uM) in lung cancer cells. |
| PC-72379 |
AC3573
HER3 inhibitor
|
AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM. |
| PC-72266 |
SPH5030
HER2 mutant inhibitor
|
SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants. |
| PC-72062 |
ErbB4 inhibitor Compound IIa
ErbB4 inhibitor
|
ErbB4 inhibitor Compound IIa is a first-in-class, potent, selective ErbB4 (HER4) inhibitor with IC50 of 17.7 nM. |
| PC-72061 |
ErbB4 inhibitor Compound Ik
ErbB4 inhibitor
|
ErbB4 inhibitor Compound Ik is a first-in-class, potent, selective ErbB4 (HER4) inhibitor with IC50 of 15.24 nM. |
| PC-72058 |
AL906
EGFR inhibitor
|
AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation). |
