| Cat. No. |
Product Name |
Information |
| PC-36109 |
TAS0728
|
TAS0728 (TAS-0728, TAS 0728) is a potent, selective, covalent, orally available inhibitor of HER2 kinase with IC50 of 36 nM in in vitro kinase assays. |
| PC-35996 |
NS-062
EGFR C797S inhibitor
|
NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR. |
| PC-35826 |
JND3229
EGFR C797S inhibitor
|
JND3229 (JND-3229) is a novel highly potent, reversible EGFR C797S mutant inhibitor, potently inhibits the kinase activities of EGFRL858R/T790M and EGFRL858R/T790M/C797 with IC50 of 5.8 nM and 30.5 nM, respectively. |
| PC-35752 |
TX2-121-1
ErbB3 inhibitor
|
TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor. |
| PC-35641 |
Alflutinib methanesulfonate
EGFR inhibitor
|
Alflutinib methanesulfonate ( Furmonertinib, AST-2818) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation. |
| PC-35640 |
Alflutinib
EGFR inhibitor
|
Alflutinib (Furmonertinib, AST-2818) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation. |
| PC-43486 |
XL-647
EGFR inhibitor
|
XL-647 (Tesevatinib, EXEL-7647, KD-019) is a novel spectrum-selective kinase inhibitor that potently inhibits the EGFR, ErbB2, KDR and EphB4 with IC50 of 0.3, 16, 1.5 and 1.4 nM, respectively. |
| PC-63499 |
TAS6417
EGFR Ex20Ins inhibitor
|
Zipalertinib (TAS6417, CLN-081) is a novel potent, selective inhibitor of EGFR exon 20 insertion mutations with IC50 of 1.1-8.0 nM, >100-fold selectivity over WT EGFR. |
| PC-43452 |
Dacomitinib
EGFR inhibitor
|
Dacomitinib (PF-00299804, PF-299804) is a potent, irreversible, orally active pan-ErbB receptor tyrosine kinase inhibitor with IC50 of 6, 45.7 and 73.7 for EGFR, ERBB2 and ERBB4, respectively. |
| PC-43436 |
OSI-420
EGFR inhibitor
|
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor for treatment of NSCLC.. |
| PC-63474 |
Simotinib
EGFR inhibitor
|
Simotinib (SIM-6802) is a novel potent, selective and orally bioavailable EGFR inhibitor with IC50 of 19.9 nM. |
| PC-63309 |
Epertinib
EGFR/HER2 inhibitor
|
Epertinib (S-222611) is a novel potent, orally active, reversible EGFR and HER2 inhibitor with IC50 of 1.48, 7.15 and 2.49 nM for EGFR, HER2 and HER4, respectively. |
