| Cat. No. |
Product Name |
Information |
| PC-21782 |
HSL119
HUNK inhibitor
|
HSL119 (HSL-119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays. |
| PC-21761 |
BI-4732
EGFR inhibitor
|
BI-4732 is a potent, highly BBB penetrant, fourth-generation EGFR inhibitor against EGFR activating mutations, including C797S. |
| PC-21566 |
BDTX-1535
EGFR inhibitor
|
Silevertinib (BDTX-1535) is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC. |
| PC-21322 |
STX-721
EGFR inhibitor
|
Elticertinib (STX-721) is a potent, selective, irreversible, orally active inhibitor of EGFR/HER2 ex20ins mutants with IC50 of 5.4 nM and 5.8 nM for cellular Ba/F3 EGFR ex20insASV and insSVD mutant activity, respectively. |
| PC-21212 |
MTX-241F
EGFR/PI3K inhibitor
|
MTX-241F (MTX241F) is a potent, highly selective and brain-penetrant inhibitor of EGFR, PI3K and DNA-PK with IC50 of 3 nM, 87 nM (PI3Kα) and 5.5 nM, respectively. |
| PC-20781 |
Mubritinib
HER2 inhibitor
|
Mubritinib (TAK-165) is a potent inhibitor of human epidermal growth factor receptor 2 (HER2, ERBB2) tyrosine kinase with IC50 of 6 nM, also is a potent Complex I inhibitor with IC50 of 51 nM. |
| PC-20669 |
Zongertinib
HER2 inhibitor
|
Zongertinib (BI 1810631, BI-1810631) is a potent, selective HER2 inhibitor, binds to the TKD of HER2 while sparing wild-type EGFR. |
| PC-20174 |
ER121
EGFR inhibitor
|
ER121 (ER-121, SGI-078) is a potent, dual kinase inhibitor targeting both mutant EGFR and activated erbB2 with IC50 of 0.08/0.15 nM (EGFR C797S/EGFR WT, ATP=10 uM). |
| PC-20044 |
Mifanertinib
EGFR inhibitor
|
Mifanertinib (Mefatinib free base) is a potent selective EGFR and HER2 kinase inhibitor with potential for for treatment of cancer. |
| PC-49519 |
HCD3514
EGFR C797S inhibitor
|
HCD3514 is a novel potent, selective, fourth-generation EGFR inhibitor targeting C797S triple mutation, strongly inhibits EGFRL858R/T790M/C797S and EGFR19del/T790M/C797S mutations with IC50 of 1.0 and 2.0 nM, respectively. |
| PC-49395 |
TAS2940
pan-ERBB inhibitor
|
TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor with IC50 of 5.6 nM、2.1 nM and 1.0 nM for HER2、HER2 V777L and A775_G776insYVMA, respectively. |
| PC-49365 |
EGFR inhibitor 57
EGFR L858R inhibitor
|
EGFR inhibitor 57 is a novel potent, selective, allosteric fourth-generation EGFR L858R inhibitor, overcomes EGFRC797S-mediated resistance in NSCLC harboring the activating EGFRL858R mutation. |
