| Cat. No. |
Product Name |
Information |
| PC-38578 |
JBJ-08-178-01
HER2 inhibitor
|
JBJ-08-178-01 is a potent, selective and covalent HER2 inhibitor with IC50 of 2.21 nM and 7.04 nM for HER2 WT and EGFR WT, targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification (IC50 values<50 nM). |
| PC-38536 |
TX1-85-1
ErbB3 inhibitor
|
TX1-85-1 is a potent, selective, irreversible and covalent inhibitor of pseudokinase Her3 (ErbB3) with IC50 of 23 nM in FRET-based binding assay. |
| PC-38347 |
ASK120067
EGFR mutant inhibitor
|
ASK120067 (Limertinib) is a novel third-generation inhibitor of EGFR T790M (L858R/T790M IC50=0.3 nM, T790M IC50=0.5 nM), with selectivity over EGFR WT (IC50=6 nM). |
| PC-38346 |
TAS-121
EGFR mutant inhibitor
|
TAS-121 (TAS 121) is an orally available, potent, novel third-generation EGFR-TKI that selectively targets EGFR activating and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38345 |
Oritinib mesylate
mutant EGFR inhibitor
|
Oritinib mesylate (SH-1028) is an irreversible third-generation EGFR inhibitor, selectively and specifically inhibits EGFR active mutations and T790M resistance mutations, sparing wild-type EGFR. |
| PC-38344 |
Oritinib
mutant EGFR inhibitor
|
Oritinib (SH-1028) is an irreversible third-generation EGFR inhibitor, selectively and specifically inhibits EGFR active mutations and T790M resistance mutations, sparing wild-type EGFR. |
| PC-73366 |
JBJ-09-063
EGFR mutant inhibitor
|
JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain. |
| PC-73153 |
Mobocertinib
EGFR Ex20Ins inhibitor
|
Mobocertinib (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73140 |
BDTX-189
EGFR mutant inhibitor
|
BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants. |
| PC-73104 |
BI-4020
EGFR mutant inhibitor
|
BI-4020 (BI 4020) is a potent, next generation, wt-sparing inhibitor of EGFR mutant T790M and/or C797S, and EGFRdel19 T790M C797S (0.2 nM). |
| PC-73088 |
DBPR112
EGFR mutant inhibitor
|
DBPR112 (DBPR 112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations. |
| PC-72985 |
(Rac)-JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
(Rac)-JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
