| Cat. No. |
Product Name |
Information |
| PC-49395 |
TAS2940
pan-ERBB inhibitor
|
TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor with IC50 of 5.6 nM、2.1 nM and 1.0 nM for HER2、HER2 V777L and A775_G776insYVMA, respectively. |
| PC-49365 |
EGFR inhibitor 57
EGFR L858R inhibitor
|
EGFR inhibitor 57 is a novel potent, selective, allosteric fourth-generation EGFR L858R inhibitor, overcomes EGFRC797S-mediated resistance in NSCLC harboring the activating EGFRL858R mutation. |
| PC-49235 |
DSF-102
EGFR ECD inhibitor
|
DSF-102 (DSF102) is a small molecule EGFR inhibitor that interacts with the extracellular domain (ECD) of EGFR, inhibits the interaction with the EGF instead of blocking the intracellular kinase activity, shows inhibition of EGFR dimerization with IC50 of 13.2 uM. |
| PC-49227 |
BI-1622
HER2 inhibitor
|
BI-1622 (BI 1622) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 7 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR. |
| PC-49226 |
BI-4142
HER2 inhibitor
|
BI-4142 (BI 4142) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 5 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR. |
| PC-47006 |
OBX02-011
EGFR C797S inhibitor
|
OBX02-011 is a potent, reversible, fourth-generation EGFR tyrosine kinase inhibitor (TKI) that overcomes the EGFR C797S mutation, inhibits triple mutants Del19/T790M/C797S and L858R/T790M/C797S with IC50 of 0.134 and 2.09 nM, respectively. |
| PC-38733 |
HKI-357
EGFR inhibitor
|
HKI-357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR with IC50 values of 33 and 34 nM respectively. |
| PC-38641 |
LDC0496
EGFR inhibitor
|
LDC0496 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome. |
| PC-38640 |
LDC8201
EGFR inhibitor
|
LDC8201 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome. |
| PC-38578 |
JBJ-08-178-01
HER2 inhibitor
|
JBJ-08-178-01 is a potent, selective and covalent HER2 inhibitor with IC50 of 2.21 nM and 7.04 nM for HER2 WT and EGFR WT, targets multiple HER2 activating mutations, including exon 20 insertions as well as amplification (IC50 values<50 nM). |
| PC-38536 |
TX1-85-1
ErbB3 inhibitor
|
TX1-85-1 is a potent, selective, irreversible and covalent inhibitor of pseudokinase Her3 (ErbB3) with IC50 of 23 nM in FRET-based binding assay. |
| PC-38348 |
LS-106
EGFR mutant inhibitor
|
LS-106 is a novel, fourth-generation EGFR inhibitor against C797S mutation, targeting both EGFR19del/T790M/C797S and EGFRL858/T790M/C797S with selectivity over EGFRwt. |
