| Cat. No. |
Product Name |
Information |
| PC-42545 |
AV-412
EGFR inhibitor
|
AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-45479 |
PD158780
EGFR inhibitor
|
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM. |
| PC-45995 |
Mutated EGFR-IN-1
EGFR inhibitor
|
Mutated EGFR-IN-1 is an analogue of AZD9291 that is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. |
| PC-26663 |
SH-1092
EGFR inhibitor
|
SH-1092 is a potent third generation EGFR inhibitor with IC50 of 0.96 nM and 6.1 nM for EGFR(T790M/L858R) and EGFR(WT) respectively. |
| PC-26083 |
JIN-A02
EGFR C797S inhibitor
|
JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance. |
| PC-25853 |
NSC228155
EGFR activator, CREB-CBP inhibitor
|
NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. |
| PC-25509 |
Tarloxotinib
pan-HER inhibitor
|
Tarloxotinib (TH-4000) is a hypoxia-activated pan-HER inhibitor, generates the active form TH-4000Effector (TH-4000E) under hypoxic condition, TH-4000E selectively inhibits EGFR, HER2 and HER4 with IC50 of <1 nM. |
| PC-24940 |
Genistein
Hsp90β inhibitor
|
Genistein (NPI 031L) is a soy isoflavone and multiple tyrosine kinases (e.g., EGFR, MKK4 (IC50=400 nM)) inhibitor, Genistein is a chemotherapeutic agent against different types of cancer. |
| PC-24922 |
EGFR-targeting peptide GE11
EGFR ligand
|
EGFR-targeting peptide GE11 is an epidermal growth factor receptor (EGFR)-specific ligand for active targeting of EGFR-overexpressing cancer cells, Conjugation of GE11 peptides to liposomal constructs enhances anti-tumor efficacies and specificities in laryngeal cancer cells. |
| PC-24584 |
ELF3-MED23 interaction inhibitor YK1
ELF3-MED23 inhibitor
|
YK1 is a potent and selective PPI inhibitor for ELF3-MED23 with IC50 of 1.18 uM, 95 % inhibition at 10 uM, attenuates the HER2-mediated oncogenic signaling cascades. |
| PC-24432 |
ErbB4 receptor agonist E4A
ErbB4 agonist
|
ErbB4 receptor agonist E4A is a small molecule ErbB4 receptor agonist, activates ErbB4 receptor and prevents neuronal senescence induced by D-Galactose through inhibition of the ferroptosis pathway. |
| PC-24172 |
YK-029A
mutant EGFR inhibitor
|
Pruvonertinib (YK-029A) is potent, wild-type sparing and mutant-selective inhibitor of EGFR T790 M and exon 20 insertion mutations with IC50 of 0.37 nM (EGFR L858R/T790 M), 29-fold selective over EGFR wt. |
