| Cat. No. |
Product Name |
Information |
| PC-24040 |
DA-0157
EGFR/ALK inhibitor
|
DA-0157 (DAJH-1050766) is a potent, dual inhibitor targeting EGFR C797S mutation, ALK-positive, and EGFR/ALK co-mutations with IC50 of 6.9 nM, 5.5 nM and 7.4 nM for EGFRDel19/T790M/C797S, ALK-WT and ALK-L1196M in Ba/F3 cell assays, respectively. |
| PC-23954 |
AZ14245445
EGFR Ex20Ins inhibitor
|
AZ14245445 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.9 in cellular SVD, (EGFR D770_N771insSVD) assays. |
| PC-23953 |
AZ14240475
EGFR Ex20Ins inhibitor
|
AZ14240475 is a potent, selective, and brain-penetrant inhibitors of EGFR Ex20Ins mutants with pIC50 of 7.6 in cellular SVD, (EGFR D770_N771insSVD) assays. |
| PC-23843 |
Canertinib
pan-ErbB inhibitor
|
Canertinib (CI-1033, PD183805) is a potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5 nM and 9.0 nM in autophosphorylation assay. |
| PC-23725 |
ERBB4 agonist EF-1
ERBB4 agonist
|
ERBB4 agonist EF-1 is a specific small molecule ERBB4 (HER4) agonist that induce ERBB4 homodimerization with EC50 of 10.5 uM in ERBB4/ERBB4 dimerization assay, reduces cell death and hypertrophy in cardiomyocytes and decreases collagen production in cardiac fibroblasts. |
| PC-23647 |
BBT-176
EGFR C797S inhibitor
|
BBT-176 is a potent, mutant-selective fourth-generation inhibitor of EGFR C797S mutations with IC50 of 4.36, 1.79, and 5.35 nM for EGFR 19Del/C797S, EGFR 19Del/T790M/C797S, and EGFR L858R/C797S, respectively. |
| PC-23646 |
EGFR triple mutant inhibitor 31
EGFR inhibitor
|
EGFR triple mutant inhibitor 31 is a potent, mutant-selective inhibitor of EGFR L858R/T790M/C797S with Ki of 2.1 nM, inhibits EGFR del19/T790M/C797S in a Ba/F3 cellular assay with IC50 of 56.9 nM. |
| PC-23313 |
TAK-285
HER2/EGFR inhibitor
|
TAK-285 is a potent, dual inhibitor of HER2 and EGFR (HER1) with IC50 of 17 nM and 23 nM, respectively. |
| PC-22888 |
DS06652923
EGFR C797S inhibitor
|
DS06652923 is a potent, and orally available EGFR-triple-mutant inhibitor with IC50 of 2.0 nM, 0.89 nM and 6.0 nM for del19/T790M/C797S, L858R/T790M/C797S and WT EGFR resceptively. |
| PC-22843 |
Arglabin
EGFR inhibitor
|
Arglabin is a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae), shows anti-inflammatory and antitumor activities, inhibits the EGFR downstream signaling pathways mTORC1 and mTORC2. |
| PC-22389 |
AZ14133346
EGFR Ex20Ins inhibitor
|
AZ14133346 is a potent and selective inhibitor of EGFR Ex20Ins with enzyme IC50 of <3 nM and cell IC50 of 85 nM, 14-fold selective over wild-type EGFR (cell IC50=1200 nM). |
| PC-22088 |
Icotinib hydrochloride
EGFR inhibitor
|
Icotinib hydrochloride (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, also inhibits mutant EGFRL858R, EGFR L858R/T790M, EGFR T790M and EGFR L861Q. |
