Cat. No. |
Product Name |
Information |
PC-21234 |
XL888
HSP90 inhibitor
|
XL888 is a potent small molecule inhibitor of HSP90 with IC50 of 24 nM, inhibits cell proliferation of multiple cancer cell types. |
PC-20807 |
HLQ2H
Hsp110-STAT3 inhibitor, Msi3 inhibitor
|
HLQ2H (Msi3 inhibitor 2H) is a first-in-class, specific inhibitor of fungal Hsp110 molecular chaperone Msi3, inhibits the holdase activity of Msi3 (IC50=5.02 uM) as well as the growth and viability of C. albicans. |
PC-20710 |
STA-9090
HSP90 inhibitor
|
Ganetespib (STA 9090) is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
PC-49868 |
Debio 0932
HSP90 inhibitor
|
Debio 0932 (CUDC-305, RGRN-305) is a highly potent, oral and BBB-penetrant HSP90 inhibitor, shows high affinity for HSP90alpha/beta and HSP90 complex derived from cancer cells with IC50 of 100 nM and 48.8 nM, respectively. |
PC-49775 |
KUNG65
Grp94 inhibitor
|
KUNG65 is a potent, selective glucose regulated protein 94 (Grp94) inhibitor with Kd value of 540 nM in fluorescence polarization assays, 73-fold selectivity over Hsp90α. |
PC-49317 |
PLTFBH
DNAJA1 inhibitor
|
PLTFBH is a cell-active small molecule inhibitor of DNAJA1, binds to and reduces protein levels of DNAJA1 and several other HSP40/J-domain proteins (JDPs), specifically reduces conformational mutp53 levels similar to PLIHZ. |
PC-38632 |
SL-145
HSP90 inhibitor
|
SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling. |
PC-73319 |
CCT361814
HSF1 inhibitor
|
CCT361814 (NXP800) is a potent, selective and orally bioavailable inhibitor of HSF1 pathway with IC50 of 94 nM (SK-OV-3, HSP72 cell-based ELISA). |
PC-73133 |
Apoptozole
HSP70 inhibitor
|
Apoptozole is a inhibits the ATPase activity of HSP70 and Hsc70 by binding to ATPase domain, induces an array of apoptotic phenotypes in cancer cells. |
PC-73076 |
DDO-5936
Hsp90-Cdc37 inhibitor
|
DDO-5936 (DDO5936) is a cell-active, specidic small-molecule inhibitor of Hsp90-Cdc37 protein-protein interaction (PPI) without ATPase inhibition, binds to Hsp 90 with Kd of 3.86 uM. |
PC-73010 |
iHSP110-33
HSP110 inhibitor
|
iHSP110-33 (Foldamer 33) is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth. |
PC-72711 |
PU-HZ151
HSP90 inhibitor
|
PU-HZ151 (Icapamespib, PU HZ151) is a specific CNS-directed epichaperome probe, with selectivity for epichaperomes over the individual chaperome membersm, inhibits HSP90 with EC50 of 5 nM in the FP assays. |