| Cat. No. |
Product Name |
Information |
| PC-62492 |
JG-98
Hsp70 inhibitor
|
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively). |
| PC-62491 |
SNX-2112
HSP90 inhibitor
|
SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β. |
| PC-62469 |
Hsp70 inhibitor YK5
Hsp70 inhibitor
|
YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells. |
| PC-62353 |
HSP70 modulator 115-7c
Hsp70 modulator
|
HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast. |
| PC-62335 |
ACO1
Grp94 inhibitor
|
ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms. |
| PC-61958 |
TAS-116
|
TAS-116 (Pimitespib, TAS116) is a novel potent, selective, orally available HSP90α/β inhibitor with Ki of 34.7, 21.3, >50,000, and >50,000 nM for HSP90α, HSP90β, GRP94, and TRAP1, respectively. |
| PC-61250 |
KW-2478
HSP90 inhibitor
|
KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo. |
| PC-70347 |
STA 2842
|
STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90. |
| PC-61032 |
4-Br-BnIm
Grp94 inhibitor
|
4-Br-BnIm is a potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α. |
| PC-60683 |
SNX-0723
HSP90 inhibitor
|
SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM. |
| PC-60660 |
KU-32
HSP90 inhibitor, Hsp70 inducer
|
KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70. |
| PC-60609 |
KU675
HSP90 inhibitor
|
KU675 is a second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively. |
