| Cat. No. |
Product Name |
Information |
| PC-42461 |
NVP-AUY922
HSP90 inhibitor
|
NVP-AUY922 (Luminespib, AUY922) is a potent and selective HSP90 inhibitor with IC50 of 21 and 7.8 nM for HSP90β and HSP90α, respectively. |
| PC-45521 |
PU-WS13
Grp94 inhibitor
|
PU-WS13 is a potent and selective Grp94 inhibitor with IC50 of 0.22 uM. |
| PC-45512 |
ML346
HSP70 activator
|
ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression. |
| PC-23505 |
DDO-6079
CDC37 inhibitor
|
DDO-6079 is a specific, allosteric small-molecule CDC37 inhibitor, binds to an allosteric site on the CDC37 M-terminal domain with ITC Kd of 1.03 uM, inhibits the binding between HSP90-CDC37 and CDC37-kinase. |
| PC-23154 |
Geldanamycin
HSP90 inhibitor
|
Geldanamycin is a small molecule Hsp90 inhibitor, binds to HSP90 and destabilizes its association with other proteins, shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria. |
| PC-22674 |
Hsp70-Bim PPI inhibitor JL-15
Hsp70-Bim inhibitor
|
Hsp70-Bim PPI inhibitor JL-15 is a potent, specific Hsp70-Bim protein-protein interaction (PPI) inhibitor with Kd of 123 nM, inhibits CML cells in the sub-μM range, overcomes BCR-ABL-independent tyrosine kinase inhibitor resistance. |
| PC-22673 |
S1g-10
Hsp70-Bim inhibitor
|
S1g-10 is a potent Hsp70-Bim protein-protein interaction (PPI) inhibitor with Kd of 688 nM, inhibits CML cells in the sub-μM range, overcomes BCR-ABL-independent tyrosine kinase inhibitor resistance in CML in vivo. |
| PC-22570 |
KUNB106
Hsp90β inhibitor
|
KUNB106 is a potent, highly selective Hsp90β inhibitor with KD of 91 nM, >275-fold selectivity vs. other isoforms. |
| PC-22213 |
NCT-58
HSP90 inhibitor
|
NCT-58 is a specfiic small molecule C-terminal HSP90 inhibitor, kills trastuzumab-resistant HER2-positive breast cancer stem-like cells, targets the C-terminal HSP90 without inducing heat shock response (HSR). |
| PC-22212 |
HVH-2930
HSP90 inhibitor
|
HVH-2930 is a specfiic small molecule C-terminal HSP90 inhibitor with SPR KD of 97.2 uM (HSP90α), reduces cell viability and induces apoptosis in HER2-positive breast cancer cells, targets the C-terminal HSP90 without inducing heat shock response (HSR). |
| PC-21759 |
HYOU1 inhibitor 52
HYOU1 inhibitor
|
HYOU1 inhibitor 52 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 0.57 uM. |
| PC-21758 |
HYOU1 inhibitor 33
HYOU1 inhibitor
|
HYOU1 inhibitor 33 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 2.57 uM. |
