| Cat. No. |
Product Name |
Information |
| PC-42457 |
17-AAG
HSP90 inhibitor
|
17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays. |
| PC-42747 |
VER-155008
Hsp70 inhibitor
|
VER-155008 is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78. |
| PC-42416 |
TRC051384
HSP70 inducer
|
TRC051384 is a potent heat shock protein 70 (HSP70) inducer, involves HSF1 activation. |
| PC-42748 |
NVP-BEP800
Hsp90 inhibitor
|
NVP-BEP800 (VER-82576) is a potent and selective Hsp90β inhibitor with IC50 of 58 nM. |
| PC-42461 |
NVP-AUY922
HSP90 inhibitor
|
NVP-AUY922 (Luminespib, AUY922) is a potent and selective HSP90 inhibitor with IC50 of 21 and 7.8 nM for HSP90β and HSP90α, respectively. |
| PC-45521 |
PU-WS13
Grp94 inhibitor
|
PU-WS13 is a potent and selective Grp94 inhibitor with IC50 of 0.22 uM. |
| PC-45512 |
ML346
HSP70 activator
|
ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression. |
| PC-26414 |
NDNA4
Hsp90α inhibitor
|
NDNA4 is a potent, selective and cell-impermeable Hsp90α inhibitor with IC50 of 0.34 uM in FP assays, >294-fold selective over Hsp90β, Grp94 and Trap1. |
| PC-26413 |
KUNA-115
Hsp90α inhibitor
|
KUNA-115 is a potent, selective Hsp90α inhibitor with IC50 of 0.84 uM in fluorescence polarization (FP) assays, >63-fold selective over Hsp90β. |
| PC-25911 |
VWK147
HSP90 CTD dimerization inhibitor
|
VWK147 is a specific second-generation small-molecule inhibitor targeting HSP90 CTD dimerization, induces cell death in cisplatin-sensitive and resistant UC cells (UCCs), and re-sensitizes resistant cells to cisplatin treatment. |
| PC-25216 |
Paeoniflorin
BACH1 inhibitor
|
Paeoniflorin (Peoniflorin) is a small molecule BACH1 inhibitor / degrader, Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity. |
| PC-24852 |
SNX-5422
HSP90 inhibitor
|
SNX-5422 (PF-04929113) is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo. |
