| Cat. No. |
Product Name |
Information |
| PC-62566 |
MAL3-101
Hsc70 inhibitor
|
MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM. |
| PC-62565 |
MKT-077
Hsp70 inhibitor
|
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53. |
| PC-62516 |
KUNB31
Hsp90β inhibitor
|
KUNB31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94. |
| PC-62493 |
HS-131
Hsp90 probe
|
HS-131 is an imaging probe of Hsp90 activity by linking it to a near-infrared (nIR) dye, HS131 uptake into cells correlated with cell membrane expression of Hsp90 and was used to image molecular subtypes of murine and human breast cancers in vitro and in murine models. |
| PC-62492 |
JG-98
Hsp70 inhibitor
|
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively). |
| PC-62491 |
SNX-2112
HSP90 inhibitor
|
SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β. |
| PC-62469 |
Hsp70 inhibitor YK5
Hsp70 inhibitor
|
YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells. |
| PC-62353 |
HSP70 modulator 115-7c
Hsp70 modulator
|
HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast. |
| PC-62335 |
ACO1
Grp94 inhibitor
|
ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms. |
| PC-62198 |
YM-1
Hsp70 inhibitor
|
YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM. |
| PC-61958 |
TAS-116
HSP90α/β inhibitor
|
TAS-116 (Pimitespib, TAS116) is a novel potent, selective, orally available HSP90α/β inhibitor with Ki of 34.7, 21.3, >50,000, and >50,000 nM for HSP90α, HSP90β, GRP94, and TRAP1, respectively. |
| PC-61797 |
NSC 145366
HSP90 inhibitor
|
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM. |
