Cat. No. |
Product Name |
Information |
PC-42456 |
Retaspimycin hydrochloride
HSP90 inhibitor
|
A water-soluble derivative of 17-AAG and HSP90 inhibitor. |
PC-42156 |
HA-15
GRP78 inhibitor
|
HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells. |
PC-42278 |
KRIBB11
HSF1 inhibitor
|
KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM. |
PC-42459 |
BIIB021
HSP90 inhibitor
|
BIIB021 is a potent, selective, orally available HSP90 inhibitor with Ki of 1.7 nM for Hsp90α. |
PC-42558 |
Alvespimycin
HSP90 inhibitor
|
Alvespimycin (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM. |
PC-42457 |
17-AAG
HSP90 inhibitor
|
17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays. |
PC-42747 |
VER-155008
Hsp70 inhibitor
|
VER-155008 is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78. |
PC-42748 |
NVP-BEP800
Hsp90β inhibitor
|
NVP-BEP800 (VER-82576) is a potent and selective Hsp90β inhibitor with IC50 of 58 nM. |
PC-42461 |
NVP-AUY922
HSP90 inhibitor
|
NVP-AUY922 (Luminespib, AUY922) is a potent and selective HSP90 inhibitor with IC50 of 21 and 7.8 nM for HSP90β and HSP90α, respectively. |
PC-45521 |
PU-WS13
Grp94 inhibitor
|
PU-WS13 is a potent and selective Grp94 inhibitor with IC50 of 0.22 uM. |
PC-22213 |
NCT-58
HSP90 inhibitor
|
NCT-58 is a specfiic small molecule C-terminal HSP90 inhibitor, kills trastuzumab-resistant HER2-positive breast cancer stem-like cells, targets the C-terminal HSP90 without inducing heat shock response (HSR). |
PC-22212 |
HVH-2930
HSP90 inhibitor
|
HVH-2930 is a specfiic small molecule C-terminal HSP90 inhibitor with SPR KD of 97.2 uM (HSP90α), reduces cell viability and induces apoptosis in HER2-positive breast cancer cells, targets the C-terminal HSP90 without inducing heat shock response (HSR). |