| Cat. No. |
Product Name |
Information |
| PC-61633 |
CCT018159
DDX39B inhibitor, Hsp90 inhibitor
|
CCT018159 is al potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM, also inhibits the ATPase activity of R-loop unwinding helicase DDX39B (UAP56). |
| PC-61302 |
HSF1A
HSF1 activator
|
HSF1A is a small molecule human HSF1 (heat shock transcription factor 1) activator, also interacts with components of the TRiC/CCT complex. |
| PC-61250 |
KW-2478
HSP90 inhibitor
|
KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo. |
| PC-70363 |
Hsp90α inhibitor A17
Hsp90α/p23 inhibitor
|
Hsp90α inhibitor A17 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1. |
| PC-70362 |
CP-9
Hsp90α/p23 inhibitor
|
CP-9 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM, 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM). |
| PC-70347 |
STA-2842
HSP90 inhibitor
|
STA-2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90. |
| PC-61032 |
4-Br-BnIm
Grp94 inhibitor
|
4-Br-BnIm is a potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α. |
| PC-60683 |
SNX-0723
HSP90 inhibitor
|
SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM. |
| PC-60670 |
PF04942847
HSP90 inhibitor
|
PF04942847 is an orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM. |
| PC-60660 |
KU-32
HSP90 inhibitor, Hsp70 inducer
|
KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70. |
| PC-60609 |
KU675
HSP90 inhibitor
|
KU675 is a second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively. |
| PC-60607 |
Gedunin
HSP90 inhibitor
|
Gedunin is a natural tetranortriterpenoid compound that inhibits Hsp90 and induce the degradation of Hsp90-dependent client proteins. |
