Cat. No. |
Product Name |
Information |
PC-21297 |
BX-2819
HSP90 inhibitor
|
BX-2819 is a potent, selective Hsp90 inhibitor with KD of 16.4 nM for human Hsp90α, also is a potent B. burgdorferi high-temperature protein G (Bb HtpG) with KD of 12 nM. |
PC-21226 |
EC144
HSP90 inhibitor
|
EC144 (EC-144) is a potent, second generation inhibitor of heat shock protein 90 (Hsp90) with IC50 of 1.1 nM in Hsp90α binding assay, degrades Her-2 in MCF-7 cells with EC50 of 14 nM. |
PC-21200 |
NVP-HSP990
HSP90 inhibitor
|
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively. |
PC-20637 |
Foldlin
HSF-1 activator
|
Foldlin is a small-molecule tool compound that reduces the protein levels of misfolded/aggregated mutant p53, without effect on contact mutants or wild-type p53, Foldlin is small-molecule HSF-1 activator. |
PC-20551 |
SOMCL-16-175
Hsp90α modulator
|
SOMCL-16-175 is a non-covalent, allosteric modulator targeting Hsp90α’s middle domain (Hsp90M) with binding Kd of 804 uM, inhibits breast cancer cell growth and proliferation. |