| Cat. No. |
Product Name |
Information |
| PC-45512 |
ML346
HSP70 activator
|
ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression. |
| PC-27908 |
HAM-1
HSP90-AHA1 inhibitor
|
HAM-1 is a small molecule modulator of Hsp90-Aha1 with KD app of 24 uM, binds to the Hsp90 N-domain, does not dissociate the Aha1-Hsp90 complex but prevents the specific interaction with the N-terminal domain of Hsp90 required for catalysis, affectes the activation and processing of Hsp90-Aha1-dependent client proteins in vivo. |
| PC-27670 |
Puerarin
GRP78 agonist
|
Puerarin is an isoflavone isolated from kudzu with multifaceted anticancer activity, also has lipid-lowering and reproductive-protective properties, binds and enhances the chaperone activity of GRP78, stabilizes steroidogenic acute regulatory protein (StAR) and upregulates its expression. |
| PC-27258 |
Evodiamine
HSP90 inhibitor, DKK2 inhibitor
|
Evodiamine ((+)-Evodiamine) is a natural alkaloid derived from Evodiae Fructus with promising antitumor activity, is a heat shock protein 90 (Hsp90) inhibitor, also exhibits a potential binding interaction with Dickkopf 2 (DKK2), suppresses the Wnt/β-catenin signaling pathway in osteosarcoma cells, suppresses cancer cell proliferation through the induction of apoptosis and cell cycle arrest. |
| PC-26801 |
HSP110 inhibitor C7
HSP110 inhibitor
|
HSP110 inhibitor C7 is a potent, second generation heat shock protein 110 (HSP110) inhibitor, inhibits STAT3 activation, inhibits colorectal cancer cells proliferation. |
| PC-26414 |
NDNA4
Hsp90α inhibitor
|
NDNA4 is a potent, selective and cell-impermeable Hsp90α inhibitor with IC50 of 0.34 uM in FP assays, >294-fold selective over Hsp90β, Grp94 and Trap1. |
| PC-25911 |
VWK147
HSP90 CTD dimerization inhibitor
|
VWK147 is a specific second-generation small-molecule inhibitor targeting HSP90 CTD dimerization, induces cell death in cisplatin-sensitive and resistant UC cells (UCCs), and re-sensitizes resistant cells to cisplatin treatment. |
| PC-25216 |
Paeoniflorin
BACH1 inhibitor
|
Paeoniflorin (Peoniflorin) is a small molecule BACH1 inhibitor / degrader, Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity. |
| PC-24852 |
SNX-5422
HSP90 inhibitor
|
SNX-5422 (PF-04929113) is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo. |
| PC-23951 |
JG-023
HSPA5/6 inhibitor
|
JG-023 is a novel isoform selective small-molecule inhibitor of HSPA5/6 with IC50 of <0.5 uM for both, shows selectivity for HSPA5 (BiP or GRP78) and HSPA6. |
| PC-23505 |
DDO-6079
CDC37 inhibitor
|
DDO-6079 is a specific, allosteric small-molecule CDC37 inhibitor, binds to an allosteric site on the CDC37 M-terminal domain with ITC Kd of 1.03 uM, inhibits the binding between HSP90-CDC37 and CDC37-kinase. |
| PC-23154 |
Geldanamycin
HSP90 inhibitor
|
Geldanamycin is a small molecule Hsp90 inhibitor, binds to HSP90 and destabilizes its association with other proteins, shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria. |
