| Cat. No. |
Product Name |
Information |
| PC-49316 |
PLIHZ
DNAJA1 inhibitor
|
PLIHZ is a small molecule inhibitor of DNAJA1 derived from the natural compound plumbagin, binds to J domain of DNAJA1 and efficiently reduces the levels of DNAJA1 and several conformational mutp53 with minimal impact on DNA contact mutp53 and wild-type p53 (wtp53). |
| PC-38908 |
DCEM1
HSP60-ClpP inhibitor
|
DCEM1 is a mitochondrial unfolded protein response (UPRmt) inhibitor, specifically disrupts HSP60-ClpP interaction in PCa cells and in vitro, suppresses prostate cancer growth in vivo. |
| PC-73397 |
Cemdomespib
Hsp90 modulator
|
Cemdomespib (KU-596) is a novobiocin analogue, C-terminal heat shock protein 90 (Hsp90) modulator that induces Hsp70 levels and manifest neuroprotective activity. |
| PC-73120 |
BC-DXI-495
HSP70-DX2 inhibitor
|
BC-DXI-495 is a specific small molecule inhibitor of AIMP2-DX2-HSP70 interaction, specifically reduced the levels of DX2 (IC50=4.2 uM) but not AIMP2-F, and the viability of lung cancer cells (EC50=14 uM). |
| PC-72553 |
DDO-6600
Hsp90 Covalent inhibitor
|
DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM). |
| PC-72333 |
Hsp90 inhibitor 5b
Hsp90 dimerization inhibitor
|
Hsp90 inhibitor 5b is a first-in-class, small molecule inhibitor of the C-terminal (CTD) Hsp90 dimerization with KD of 3.42 uM, IC50 of 1.3 uM against leukemia cell line K562. |
| PC-43120 |
HSP70-IN-27c
|
HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM. |
| PC-62650 |
HS-72
|
HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome. |
| PC-62622 |
Col 003
|
Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47. |
| PC-62621 |
AK778
|
AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. . |
| PC-62569 |
NSC 630668
|
NSC 630668 is a Hsc70 inhibitor that inhibits the endogenous and DnaJ-stimulated ATPase activity of hsc70. |
| PC-62567 |
Deoxyspergualin
|
Deoxyspergualin is a derivative of the antitumor antibiotic spergualin that binds specifically to Hsc70, also inhibits poly(rC) binding protein 2 (PCBP2).. |
