| Cat. No. |
Product Name |
Information |
| PC-72553 |
DDO-6600
Hsp90 Covalent inhibitor
|
DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM). |
| PC-72333 |
Hsp90 inhibitor 5b
Hsp90 dimerization inhibitor
|
Hsp90 inhibitor 5b is a first-in-class, small molecule inhibitor of the C-terminal (CTD) Hsp90 dimerization with KD of 3.42 uM, IC50 of 1.3 uM against leukemia cell line K562. |
| PC-43120 |
HSP70-IN-27c
|
HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM. |
| PC-62622 |
Col 003
|
Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47. |
| PC-62621 |
AK778
|
AK778 (Col001) is a small-molecule compound that inhibits the interaction of Hsp47 with collagen, competitively inhibits the interaction and causes the inhibition of collagen secretion by destabilizing the collagen triple helix. . |
| PC-62516 |
KUNB 31
|
KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94. |
| PC-62198 |
YM-1
|
YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM. |
| PC-61905 |
Epolactaene
|
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
| PC-61797 |
NSC 145366
|
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM. |
| PC-61633 |
CCT-018159
|
CCT-01815 is a novel potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM. |
| PC-61302 |
HSF1A
|
A small molecule human HSF1 (heat shock transcription factor 1) activator. |
| PC-70363 |
A-17
|
A potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1. |
