| Cat. No. |
Product Name |
Information |
| PC-35115 |
SNX-9114
HSP90 inhibitor
|
SNX-9114 (SNX9114, PF-04944733) is a small molecule Hsp90 inhibitor with excellent brain permeability. |
| PC-63505 |
Aminoxyrone
HSP90 inhibitor
|
Aminoxyrone is a novel peptidometic C-terminal HSP90 inhibitor by targeting HSP90 dimerization via the C-terminal domain (CTD) with Kd of 27.4 uM. |
| PC-63360 |
ITZ-1
HSP90 inhibitor
|
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation. |
| PC-63191 |
HSP27 inhibitor J2
HSP27 inhibitor
|
HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27, induces significant abnormal HSP27 dimer formation in cancer cells. |
| PC-62565 |
MKT-077
Telomerase inhibitor
|
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53. |
| PC-62492 |
JG-98
Hsp70 inhibitor
|
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively). |
| PC-62491 |
SNX-2112
HSP90 inhibitor
|
SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β. |
| PC-62353 |
HSP70 modulator 115-7c
Hsp70 modulator
|
HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast. |
| PC-62335 |
ACO1
Grp94 inhibitor
|
ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms. |
| PC-61958 |
TAS-116
|
TAS-116 (Pimitespib, TAS116) is a novel potent, selective, orally available HSP90α/β inhibitor with Ki of 34.7, 21.3, >50,000, and >50,000 nM for HSP90α, HSP90β, GRP94, and TRAP1, respectively. |
| PC-61250 |
KW-2478
HSP90 inhibitor
|
KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo. |
| PC-70347 |
STA 2842
|
STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90. |
