| Cat. No. |
Product Name |
Information |
| PC-72659 |
Bufalin
AHSA1 (Aha1) inhibitor
|
Bufalin is a highly toxic, effective anti-cancer compound, targets Hsp90 cochaperone AHSA1 (Aha1, Activator of HSP90 ATPase Activity 1). |
| PC-72658 |
KU-177
AHSA1 (Aha1) inhibitor
|
KU-177 (KU-177) is a selective small molecule inhibitor of Hsp90 cochaperone AHSA1 (Aha1 ,activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between Hsp90 and Aha1. |
| PC-72570 |
Hsp90α-IN-12h
Hsp90α inhibitor
|
Hsp90α-IN-12h is the first Hsp90α-selective inhibitor with IC50 of 460 nM, exhibit 48-fold selectivity versus other Hsp90 isoforms. |
| PC-72553 |
DDO-6600
Hsp90 Covalent inhibitor
|
DDO-6600 (DDO 6600) is a potent, selective, covalent inhibitor of Hsp90, covalently modifies Cys598 on Hsp90 and disrupts the interaction between Hsp90 and Cdc37 (IC50=6.67 uM). |
| PC-72448 |
YUM70
GRP78 inhibitor
|
YUM70 (YUM-70) is a derivative of 8-hydroxyquinoline targeting GRP78, and cytotoxic to pancreatic cancer cell lines (MIA PaCa-2 cell IC50=2.5 uM). |
| PC-72333 |
Hsp90 inhibitor 5b
Hsp90 dimerization inhibitor
|
Hsp90 inhibitor 5b is a first-in-class, small molecule inhibitor of the C-terminal (CTD) Hsp90 dimerization with KD of 3.42 uM, IC50 of 1.3 uM against leukemia cell line K562. |
| PC-72068 |
DTHIB
HSF1 inhibitor
|
DTHIB (Direct Targeted HSF1 InhiBitor, SISU-102) is a specific small molecule HSF1 inhibitor with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). |
| PC-72003 |
SU086
HSP90 inhibitor
|
SU086 is an inhibitor of HSP90, binds to HSP90-alpha and HSP90-beta isoforms, decreases HSP90 protein levels in prostate cancer cells. |
| PC-38267 |
SEW84
ASH ATPase inhibitor
|
SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase. |
| PC-38154 |
S1g-2
Hsp70-Bim inhibitor
|
S1g-2 (Hsp70-Bim inhibitor S1g-2) is a selective inhibitor to block interactions of Hsp70-Bim with IC50 of 0.4 uM in FPA assays, > 40-fold selectivity to target Hsp70-Bim over Bcl-2-Bim. |
| PC-38121 |
Gamitrinib TPP hexafluorophosphate
HSP90 inhibitor
|
Gamitrinib is a small molecule mitochondrial Hsp90 inhibitor, selectively targets Hsp90 network in tumor mitochondria. |
| PC-35998 |
YZ129
HSP90 inhibitor, NFAT inhibitor
|
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM. |
