| Cat. No. |
Product Name |
Information |
| PC-35390 |
JG-231
Hsp70-BAG3 inhibitor
|
JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively. |
| PC-35293 |
KBU2046
Hsp90β inhibitor
|
KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes. |
| PC-35115 |
SNX-9114
HSP90 inhibitor
|
SNX-9114 (SNX9114, PF-04944733) is a small molecule Hsp90 inhibitor with excellent brain permeability. |
| PC-63505 |
Aminoxyrone
HSP90 inhibitor
|
Aminoxyrone is a novel peptidometic C-terminal HSP90 inhibitor by targeting HSP90 dimerization via the C-terminal domain (CTD) with Kd of 27.4 uM. |
| PC-63360 |
ITZ-1
HSP90 inhibitor
|
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation. |
| PC-63191 |
HSP27 inhibitor J2
HSP27 inhibitor
|
HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27, induces significant abnormal HSP27 dimer formation in cancer cells. |
| PC-62650 |
HS-72
Hsp70i inhibitor
|
HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome. |
| PC-62569 |
NSC 630668
Hsc70 inhibitor
|
NSC 630668 is a Hsc70 inhibitor that inhibits the endogenous and DnaJ-stimulated ATPase activity of hsc70. |
| PC-62567 |
Deoxyspergualin
Hsc70 inhibitor, PCBP2 inhibitor
|
Deoxyspergualin is a derivative of the antitumor antibiotic spergualin that binds specifically to Hsc70, also inhibits poly(rC) binding protein 2 (PCBP2).. |
| PC-62566 |
MAL3-101
Hsc70 inhibitor
|
MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM. |
| PC-62565 |
MKT-077
Telomerase inhibitor
|
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53. |
| PC-62493 |
HS-131
Hsp90 probe
|
HS-131 is an imaging probe of Hsp90 activity by linking it to a near-infrared (nIR) dye, HS131 uptake into cells correlated with cell membrane expression of Hsp90 and was used to image molecular subtypes of murine and human breast cancers in vitro and in murine models. |
