| Cat. No. |
Product Name |
Information |
| PC-20807 |
HLQ2H
Hsp110-STAT3 inhibitor, Msi3 inhibitor
|
HLQ2H (Msi3 inhibitor 2H) is a first-in-class, specific inhibitor of fungal Hsp110 molecular chaperone Msi3, inhibits the holdase activity of Msi3 (IC50=5.02 uM) as well as the growth and viability of C. albicans. |
| PC-20710 |
Ganetespib
HSP90 inhibitor
|
Ganetespib (STA-9090) is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
| PC-20709 |
STA-1474
HSP90 inhibitor
|
STA-1474 is a water soluble prodrug of Ganetespib (STA 9090), which is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
| PC-49868 |
Debio 0932
HSP90 inhibitor
|
Debio 0932 (CUDC-305, RGRN-305) is a highly potent, oral and BBB-penetrant HSP90 inhibitor, shows high affinity for HSP90alpha/beta and HSP90 complex derived from cancer cells with IC50 of 100 nM and 48.8 nM, respectively. |
| PC-49842 |
PST inhibitor peptide-8
Pancreastatin inhibitor
|
PST inhibitor peptide-8 (PSTi8) is a potent pancreastatin (PST) inhibitor, competes with PST on GRP78 receptor binding and rescues PST-induced insulin resistance (IR) both in vitro and in vivo. |
| PC-49775 |
KUNG65
Grp94 inhibitor
|
KUNG65 is a potent, selective glucose regulated protein 94 (Grp94) inhibitor with Kd value of 540 nM in fluorescence polarization assays, 73-fold selectivity over Hsp90α. |
| PC-49670 |
VER-50589
Hsp90 inhibitor
|
VER-50589 (VER50589) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 21 nM and Kd value of 4.5 nM. |
| PC-49669 |
VER-49009
Hsp90 inhibitor
|
VER-49009 (CCT0129397, VER49009) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 25 nM and Kd value of 78 nM, inhibits ATPase activity of full length yeast Hsp90 protein with IC50 of 0.14 uM. |
| PC-49601 |
Grp78 inhibitor 8
Grp78 inhibitor
|
Grp78 inhibitor 8 is a potent, isoform-selective inhibitor of the ER Resident Chaperone Grp78 (HSPA5) with IC50 of 0.59 uM. |
| PC-49317 |
PLTFBH
DNAJA1 inhibitor
|
PLTFBH is a cell-active small molecule inhibitor of DNAJA1, binds to and reduces protein levels of DNAJA1 and several other HSP40/J-domain proteins (JDPs), specifically reduces conformational mutp53 levels similar to PLIHZ. |
| PC-49316 |
PLIHZ
DNAJA1 inhibitor
|
PLIHZ is a small molecule inhibitor of DNAJA1 derived from the natural compound plumbagin, binds to J domain of DNAJA1 and efficiently reduces the levels of DNAJA1 and several conformational mutp53 with minimal impact on DNA contact mutp53 and wild-type p53 (wtp53). |
| PC-38908 |
DCEM1
HSP60-ClpP inhibitor
|
DCEM1 is a mitochondrial unfolded protein response (UPRmt) inhibitor, specifically disrupts HSP60-ClpP interaction in PCa cells and in vitro, suppresses prostate cancer growth in vivo. |
