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Cat. No. Product Name Information
PC-38632

SL-145

HSP90 inhibitor

SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling.
PC-73397

Cemdomespib

Hsp90 modulator

Cemdomespib (KU-596) is a novobiocin analogue, C-terminal heat shock protein 90 (Hsp90) modulator that induces Hsp70 levels and manifest neuroprotective activity.
PC-73319

CCT361814

HSF1 inhibitor

CCT361814 (NXP800) is a potent, selective and orally bioavailable inhibitor of HSF1 pathway with IC50 of 94 nM (SK-OV-3, HSP72 cell-based ELISA).
PC-73133

Apoptozole

HSP70 inhibitor

Apoptozole is a inhibits the ATPase activity of HSP70 and Hsc70 by binding to ATPase domain, induces an array of apoptotic phenotypes in cancer cells.
PC-73120

BC-DXI-495

HSP70-DX2 inhibitor

BC-DXI-495 is a specific small molecule inhibitor of AIMP2-DX2-HSP70 interaction, specifically reduced the levels of DX2 (IC50=4.2 uM) but not AIMP2-F, and the viability of lung cancer cells (EC50=14 uM).
PC-73076

DDO-5936

Hsp90-Cdc37 inhibitor

DDO-5936 (DDO5936) is a cell-active, specidic small-molecule inhibitor of Hsp90-Cdc37 protein-protein interaction (PPI) without ATPase inhibition, binds to Hsp 90 with Kd of 3.86 uM.
PC-73010

iHSP110-33

HSP110 inhibitor

iHSP110-33 (Foldamer 33) is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth.
PC-72711

PU-HZ151

HSP90 inhibitor

PU-HZ151 (Icapamespib, PU HZ151) is a specific CNS-directed epichaperome probe, with selectivity for epichaperomes over the individual chaperome membersm, inhibits HSP90 with EC50 of 5 nM in the FP assays.
PC-72710

PU-H71

Hsp90 inhibitor

PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells.
PC-72704

AIMP2-DX2 inhibitor 1

AIMP2-DX2 inhibitor

AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM).
PC-72659

Bufalin

AHSA1 (Aha1) inhibitor

Bufalin is a highly toxic, effective anti-cancer compound, targets Hsp90 cochaperone AHSA1 (Aha1, Activator of HSP90 ATPase Activity 1).
PC-72658

KU-177

AHSA1 (Aha1) inhibitor

KU-177 (KU-177) is a selective small molecule inhibitor of Hsp90 cochaperone AHSA1 (Aha1 ,activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between Hsp90 and Aha1.

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