| Cat. No. |
Product Name |
Information |
| PC-49316 |
PLIHZ
DNAJA1 inhibitor
|
PLIHZ is a small molecule inhibitor of DNAJA1 derived from the natural compound plumbagin, binds to J domain of DNAJA1 and efficiently reduces the levels of DNAJA1 and several conformational mutp53 with minimal impact on DNA contact mutp53 and wild-type p53 (wtp53). |
| PC-38908 |
DCEM1
HSP60-ClpP inhibitor
|
DCEM1 is a mitochondrial unfolded protein response (UPRmt) inhibitor, specifically disrupts HSP60-ClpP interaction in PCa cells and in vitro, suppresses prostate cancer growth in vivo. |
| PC-38632 |
SL-145
HSP90 inhibitor
|
SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling. |
| PC-73397 |
Cemdomespib
Hsp90 modulator
|
Cemdomespib (KU-596) is a novobiocin analogue, C-terminal heat shock protein 90 (Hsp90) modulator that induces Hsp70 levels and manifest neuroprotective activity. |
| PC-73319 |
CCT361814
HSF1 inhibitor
|
CCT361814 (NXP800) is a potent, selective and orally bioavailable inhibitor of HSF1 pathway with IC50 of 94 nM (SK-OV-3, HSP72 cell-based ELISA). |
| PC-73133 |
Apoptozole
HSP70 inhibitor
|
Apoptozole is a inhibits the ATPase activity of HSP70 and Hsc70 by binding to ATPase domain, induces an array of apoptotic phenotypes in cancer cells. |
| PC-73120 |
BC-DXI-495
HSP70-DX2 inhibitor
|
BC-DXI-495 is a specific small molecule inhibitor of AIMP2-DX2-HSP70 interaction, specifically reduced the levels of DX2 (IC50=4.2 uM) but not AIMP2-F, and the viability of lung cancer cells (EC50=14 uM). |
| PC-73076 |
DDO-5936
Hsp90-Cdc37 inhibitor
|
DDO-5936 (DDO5936) is a cell-active, specidic small-molecule inhibitor of Hsp90-Cdc37 protein-protein interaction (PPI) without ATPase inhibition, binds to Hsp 90 with Kd of 3.86 uM. |
| PC-73010 |
iHSP110-33
HSP110 inhibitor
|
iHSP110-33 (Foldamer 33) is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth. |
| PC-72711 |
PU-HZ151
HSP90 inhibitor
|
PU-HZ151 (Icapamespib, PU HZ151) is a specific CNS-directed epichaperome probe, with selectivity for epichaperomes over the individual chaperome membersm, inhibits HSP90 with EC50 of 5 nM in the FP assays. |
| PC-72710 |
PU-H71
Hsp90 inhibitor
|
PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells. |
| PC-72704 |
AIMP2-DX2 inhibitor 1
AIMP2-DX2 inhibitor
|
AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM). |
