| Cat. No. |
Product Name |
Information |
| PC-36162 |
AK106-001616
cPLA2 inhibitor
|
AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme). |
| PC-36138 |
FKGK18
iPLA2 inhibitor
|
FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM. |
| PC-36137 |
GK563
iPLA2 inhibitor
|
GK563 (GK-563) is a potent, selective inhibitor of Ca2+-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM, >20,000-fold selectivity over GIVA cPLA2. |
| PC-36093 |
IS-741
cPLA2 inhibitor
|
IS-741 (Fuzapladib, IS741) is a synthetic anti-inflammatory agent that shows inhibitory effect on cytosolic phospholipase A2 (cPLA2).. |
| PC-35979 |
LEI110
PLA2G16 inhibitor
|
LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6). |
| PC-35798 |
HT105
CD95-PLCγ1 inhibitor
|
HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM. |
| PC-35797 |
DB550
CD95-PLCγ1 inhibitor
|
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM. |
| PC-35796 |
DO264
ABHD12 inhibitor
|
DO264 (DO-264) is a potent, selective, reversible and vivo-active inhibitor of ABHD12 that inhibits ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain with IC50 of 2.8 nM. |
| PC-35307 |
sPLA2-X inhibitor 31
sPLA2-X inhibitor
|
sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively. |
| PC-35258 |
ARN19874
NAPE-PLD inhibitor
|
ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM. |
| PC-43523 |
U-73122
PLC inhibitor
|
U-73122 is an unselective phospholipase C (PLC) inhibitor, inhibits agonist-induced platelet aggregation with IC50 of 1-5 uM. |
| PC-43510 |
Varespladib
sPLA2 inhibitor
|
Varespladib (LY315920, A-002) is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) with IC50 of 9 nM, 40-fold less active against group IB, pancreatic sPLA2 and inactive against cytosolic PLA2. |
