| Cat. No. |
Product Name |
Information |
| PC-35307 |
sPLA2-X inhibitor 31
sPLA2-X inhibitor
|
sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively. |
| PC-35258 |
ARN19874
NAPE-PLD inhibitor
|
ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM. |
| PC-43523 |
U-73122
PLC inhibitor
|
U-73122 is an unselective phospholipase C (PLC) inhibitor, inhibits agonist-induced platelet aggregation with IC50 of 1-5 uM. |
| PC-43510 |
Varespladib
sPLA2 inhibitor
|
Varespladib (LY315920, A-002) is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) with IC50 of 9 nM, 40-fold less active against group IB, pancreatic sPLA2 and inactive against cytosolic PLA2. |
| PC-63287 |
Edelfosine
PLC inhibitor
|
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits PLC with IC50 of 9.6 uM in fibroblasts and adenocarcinoma cells. |
| PC-43220 |
FIPI
PLD1/PLD2 inhibitor
|
FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2. |
| PC-63190 |
VU0155069
PLD1 inhibitor
|
VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM). |
| PC-63003 |
SB-435495
Lp-PLA2 inhibitor
|
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM. |
| PC-62407 |
LYPLAL1-IN-11
LYPLAL1 inhibitor
|
LYPLAL1-IN-11 is a potent, selective, covalent inhibitor of lysophospholipase-like 1 (LYPLAL1) with IC50 of 6 nM. |
| PC-62332 |
ML378
APT1/APT2 inhibitor
|
ML378 (CID71710938, JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively. |
| PC-62262 |
KC01
ABHD16A inhibitor
|
KC01 is a potent and selective inhibitor of ABHD16A with IC50 of 90 nM for hABHD16A, 520 nM for mABHD16A. |
| PC-62138 |
ML395
PLD2 inhibitor
|
ML395 is a potent, selective, allosteric phospholipase D2 (PLD2) inhibitor with cellular IC50 of 360 nM, shows >80-fold selectivity over PLD1 (IC50>30 uM). |
