| Cat. No. |
Product Name |
Information |
| PC-20199 |
LE135
RARβ inhibitor
|
LE135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Ki values=0.22 and 1.4 μM, respectively), highly selective over RARγ and RXRα. |
| PC-49025 |
Ro41-5253
RARα antagonist
|
Ro 41-5253 is a potent and selective retinoic acid receptor-α (RARα) antagonist with IC50 of 16 nM. |
| PC-35992 |
Fenretinide
RAR agonist
|
Fenretinide (NSC 374551, 4-HPR, 4-Hydroxyphenyl retinamide) is a synthetic retinoid derivative with potential antineoplastic and chemopreventive activities, binds to and activates RARs, thereby inducing cell differentiation and apoptosis in some tumor cell types.. |
| PC-35622 |
UAB30
RXR agonist
|
UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis. |
| PC-35535 |
HX600
NURR1 (NR4A2) agonist
|
HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers. |
| PC-35516 |
AC261066
RARβ2 agonist
|
AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
| PC-35171 |
Trifarotene
RARγ agonist
|
Trifarotene (CD5789, CD-5789) is a potent and selective RARγ agonist with EC50 of 7.7 nM, 500- and 125-fold selectivity over RARα and RARβ. |
| PC-63510 |
WYC-209
RAR agonist
|
WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR). |
| PC-62836 |
LY-2955303
RARγ antagonist
|
LY-2955303 is a potent and selective RARγ antagonist with binding Ki of 1.09 nM, displays >1000-fold selectivity against RARα and RARβ. |
| PC-62291 |
CD 437
RARγ agonist
|
CD437 (CD 437) is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, directly inhibits DNA polymerase α with IC50 of 22 nM, also acts as an RARγ agonist. |
| PC-70298 |
UVI-3003
RXR antagonist
|
UVI-3003 (UVI 3003) is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity, inhibits xenopus and human RXRα in Cos7 cells with IC50 of 0.22 and 0.24 uM, respectively. |
| PC-70297 |
SR-11237
RXR agonist
|
SR-11237 (BMS-649) is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity. |
