| Cat. No. |
Product Name |
Information |
| PC-25834 |
ML-007
M1/M4 mAChR agonist
|
ML-007 (Betovumeline) is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors. |
| PC-23641 |
VU0467319
M1 mAChR PAM
|
VU0467319 (VU319, ACP-319) is a potent, selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 492 nM, with minimal M1 agonism (EC50 > 30 uM). |
| PC-22975 |
MK-7622
M1 mAChR PAM
|
MK-7622 is a potent, selective and CNS penetrant M1 muscarinic receptor positive allosteric modulator (PAM). |
| PC-20509 |
PIPE-359
M1 mAChR antagonist
|
PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R). |
| PC-20508 |
VU0415248
M1 mAChR antagonist
|
VU0415248 is a highly selective antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 0.4 uM and 0.18 uM for hM1R and rM1R, respectively. |
| PC-20104 |
Deschloroclozapine
DREADD agonist
|
Deschloroclozapine (DCZ) is a high-affinity and selective agonist for muscarinic-based DREADDs, shows nanomolar affinity for [3H]QNB-labeled hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
| PC-49312 |
CHF-6366
MABA
|
CHF-6366 is a novel potent muscarinic antagonist and β2 agonist (MABA) with pKi of 10.2 and 11.4, respectively. |
| PC-49070 |
VU0405645
M1 Receptor PAM
|
VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM. |
| PC-38388 |
Emraclidine
M4 mAChR PAM
|
Emraclidine (CVL-231) is a potent, selective positive allosteric modulator (PAM) of M4 muscarinic receptor subtype in development for schizophrenia. |
| PC-73364 |
VU6019650
M5 mAChR antagonist
|
VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4. |
| PC-73158 |
JHU37152
DREADD agonist
|
JHU37152 is a high affinity and highly potent activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro. |
| PC-72979 |
AZD8871
M3 β2 (MABA)
|
AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor. |
